蛋白

ACAT2, 1-397aa, 人类, 多聚组氨酸标签, 大肠杆菌

MBS203511

0.1毫克

310美元

重组蛋白

ACAT2, 1-397aa, 人类, 多聚组氨酸标签, 大肠杆菌

ACAT2

ACTL; Acetyl-CoA acetyltransferase; cytosolic

acetyl-CoA acetyltransferase, cytosolic isoform 1; Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase, cytosolic; acetoacetyl Coenzyme A thiolase; acetyl-CoA transferase-like protein; cytosolic acetoacetyl-CoA thiolase; acetyl-CoA acetyltransferase 2; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase

ACAT2

ACAT2;ACAT2;ACTL

THIC_HUMAN

397

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNAG SDPVVIVSAA RTIIGSFNGA LAAVPVQDLG STVIKEVLKR ATVAPEDVSE VIFGHVLAAG CGQNPVRQAS VGAGIPYSVP AWSCQMICGS GLKAVCLAVQ SIGIGDSSIV VAGGMENMSK APHLAYLRTG VKIGEMPLTD SILCDGLTDA FHNCHMGITA ENVAKKWQVS REDQDKVAVL SQNRTENAQK AGHFDKEIVP VLVSTRKGLI EVKTDEFPRH GSNIEAMSKL KPYFLTDGTG TVTPANASGI NDGAAAVVLM KKSEADKRGL TPLARIVSWS QVGVEPSIMG IGPIPAIKQA VTKAGWSLED VDIFEINEAF AAVSAAIVKE LGLNPEKVNI EGGAIALGHP LGASGCRILV TLLHTLERMG RSRGVAALCI GGGMGIAMCV QRE

> 95% by SDS - PAGE

液体。 在20 mM三羟甲基氨基甲烷氯化氢缓冲液(pH8.0)含0.1M氯化钠, 1mM DTT, 10% 甘油

1毫克/毫升(由布拉德福德Bradford检测确定)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

十二烷基磺酸钠-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

酶&蛋白酶

ACAT2 is an enzyme involved in lipid metabolism. It participates in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. ACAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. ACAT2 deficiency contributes to severe mental retardation and hypotonus. Recombinant human ACAT2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Alger HM., et al. (2010) J Biol Chem. 285(19):14267-74. Bryleva EY., et al. (2010) Proc Natl Acad Sci u S A. 107(7):3081-6.

148539872

NP_005882

NM_005891.2

45.4 kDa (433aa) confirmed by MALDI-TOF

Butanoate Metabolism Pathway (83007); Butanoate Metabolism Pathway (391); C5 Isoprenoid Biosynthesis, Mevalonate Pathway (413387); C5 Isoprenoid Biosynthesis, Mevalonate Pathway (468288); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296)

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]. Protein type: Carbohydrate Metabolism - butanoate; EC 2.3.1.9; Amino Acid Metabolism - tryptophan; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - lysine degradation; Carbohydrate Metabolism - pyruvate; Acetyltransferase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lipid Metabolism - fatty acid. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus. Molecular Function: acetyl-CoA C-acetyltransferase activity. Biological Process: lipid metabolic process. Disease: Acetyl-coa Acetyltransferase-2 Deficiency

0.1毫克

310美元

0.5毫克

720