抗体

生物素链接抗体整合素乙3(ITGb3)

MBS2005584

0.1毫克

235美元

多克隆

兔

生物素

免疫印迹, 免疫组化, 免疫细胞化学

抗体

生物素链接抗体整合素乙3(ITGb3)

[整合素乙3(ITGb3)]

[整合素乙3;整合素乙3;整合素乙3;血小板膜糖蛋白IIIa;整合素, 乙3(血小板糖蛋白Ⅲa, 抗原CD61);血小板膜糖蛋白IIIa]

[ITGb3]

[ITGB3;ITGB3;GT;CD61;GP3A;BDPLT2;糖蛋白Ⅲa;BDPLT16;GP3A;糖蛋白Ⅲa]

ITB3_HUMAN

多克隆

兔

Antigen-specific Affinity Chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

0.5毫克/毫升

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

免疫印迹;免疫组化;免疫细胞化学

Western blotting: 0.5-2 Ug/mL;1:250-1000. Immunohistochemistry: 5-20 Ug/mL;1:25-100. Immunocytochemistry: 5-20 Ug/mL;1:25-100. Optimal working dilutions must be determined by end user.

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: Biotin. Traits: Liquid. Immunogen: Recombinant ITGb3 (Asp135~Ile377) expressed in E.coli.

生物素抗体

47078292

NP_000203.2

NM_000212.2

P05106

Arf6 Signaling Events Pathway (138034); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Cell Surface Interactions At The Vascular Wall Pathway (106062); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM Proteoglycans Pathway (833812)

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: filopodium membrane; platelet alpha granule membrane; cell surface; focal adhesion; microvillus membrane; integral to plasma membrane; plasma membrane; melanosome; nucleus; integrin complex; receptor complex. Molecular Function: identical protein binding; protein binding; protease binding; extracellular matrix binding; vascular endothelial growth factor receptor 2 binding; fibronectin binding; platelet-derived growth factor receptor binding; protein disulfide isomerase activity; cell adhesion molecule binding; receptor activity. Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; protein folding; wound healing; cell-matrix adhesion; smooth muscle cell migration; mesodermal cell differentiation; negative chemotaxis; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet degranulation; cell-substrate junction assembly; cell growth; cell adhesion; integrin-mediated signaling pathway; platelet activation; regulation of bone resorption; cell migration; negative regulation of lipoprotein metabolic process; angiogenesis involved in wound healing; cell-substrate adhesion; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; tube development; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration. Disease: Myocardial Infarction, Susceptibility To; Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16

0.1毫克

235美元

0.2毫克

350

1毫克

835