Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody | MyBioSource MBS190548 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody

MBS190548

规格 :

0.1毫克

价格 :

395美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

S8B-1

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学

更多信息或购买 :

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产品信息

目录号 :

MBS190548

产品类型 :

抗体

产品全称 :

Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody

产品简称 :

Cav-beta 2 Ca+2 Channel

其他名称 :

voltage-dependent L-type calcium channel subunit beta-2; Voltage-dependent L-type calcium channel subunit beta-2; voltage-dependent L-type calcium channel subunit beta-2; CAB2; calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; Calcium channel voltage-dependent subunit beta 2

其他基因名称 :

Cacnb2;Cacnb2;Cacnlb2;Cacnlb2

UniProt数据库进入名 :

CACB2_RAT

克隆性 :

单克隆

抗体亚型 :

IgG1

克隆 :

S8b-1

宿主 :

小鼠

反应物种 :

人类, 小鼠, 大鼠

序列位置 :

189-205

特异性 :

Cav beta 2 Ca+2 Channel. This antibody recognizes human, mouse, and rat Cavbeta2. It does not cross-react with Cav beta1, Cav beta3, or Cav beta4.

形式 :

100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

储存稳定性 :

This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.

检测过的应用 :

免疫印迹 ;免疫组化;免疫细胞化学;免疫荧光

应用笔记 :

Immunoblotting: use at 1-10ug/ml. A band of ~78kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate

其它信息1 :

Antigen: Synthetic peptide corresponding to aa 189-205 of rat Cavbeta2 (RSPKPSANSVTSPHSKE) (accession no.NP_446303).

其他信息2 :

Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

产品描述 :

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cavbeta subunits are involved in the transport of the pore-forming alpha1 subunit to the plasma membrane. They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the poreforming subunit to the target membrane.

NCBI GI登录号 :

16758716

NCBI登录号 :

NP_446303.1

NCBI基因登录号 :

NM_053851.1

UniProt数据库登录号 :

Q8VGC3

NCBI分子量 :

73,226 Da

NCBI信号通路 :

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117251); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Cardiac Muscle Contraction Pathway (93346); Cardiac Muscle Contraction Pathway (93992); Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway (368673); Diabetes Pathways (368509); Dilated Cardiomyopathy Pathway (121476); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114014); Hypertrophic Cardiomyopathy (HCM) Pathway (106591)

NCBI总结 :

auxillary subunit of the L-type Ca(2+) channel [RGD]

UniProt数据库总结 :

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, calcium. Cellular Component: voltage-gated calcium channel complex; sarcolemma. Molecular Function: voltage-gated calcium channel activity; protein domain specific binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein kinase binding. Biological Process: synaptic transmission; visual perception; calcium ion transport; positive regulation of calcium ion transport; neuromuscular junction development

尺寸1 :

0.1毫克

价格1 :

395美元

更多信息或购买 :

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公司信息