抗CYP11B1抗体 | MyBioSource MBS175139 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

抗CYP11B1抗体

MBS175139

规格 :

0.1毫克

价格 :

245美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类

应用 :

免疫印迹

更多信息或购买 :

MyBioSource 产品网页

产品信息

目录号 :

MBS175139

产品类型 :

抗体

产品全称 :

抗CYP11B1抗体

产品简称 :

CYP11B1

产品名称同义词 :

Cytochrome P450 11B1, mitochondrial; cytochrome P450, family 11, subfamily B, polypeptide 1; CPN1 antibody; CYP11B antibody; CYPXIB1 antibody; Cytochrome P 450c11 antibody; Cytochrome P450 11B1, mitochondrial antibody; Cytochrome p450 XIB1 antibody; Cytochrome P450, family 11, subfamily B, polypeptide 1 antibody; Cytochrome P450, subfamily XIB(steroid 11 beta hydroxylase), polypeptide 1 antibody; Cytochrome P450C11 antibody; FHI antibody; P 450C11 antibody; P450C11 antibody; S11BH antibody; Steroid 11 beta hydroxylase antibody; Steroid 11 beta monooxygenase antibody

其他名称 :

Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B1, mitochondrial; cytochrome P450 11B1, mitochondrial; CYPXIB1; cytochrome P450C11; cytochrome P-450c11; cytochrome p450 XIB1; steroid 11-beta-hydroxylase; steroid 11-beta-monooxygenase; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 1; CYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase (EC:1.14.15.4)

产品基因名称 :

CYP11B1

其他基因名称 :

CYP11B1;CYP11B1;FHI;CPN1;CYP11B;P450C11;S11BH;细胞色素P450C11

UniProt数据库进入名 :

C11B1_HUMAN

克隆性 :

多克隆

抗体亚型 :

IgG

宿主 :

兔

反应物种 :

人类

序列长度 :

503

纯度 :

免疫原亲和纯化

形式 :

冻干

储存稳定性 :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

检测过的应用 :

免疫印迹(免疫印迹)

其它信息1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11B1 (436-450aa RNFYHVPFGFGMRQC).

其他信息2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

产品描述 :

Description: Rabbit IgG polyclonal antibody for Cytochrome P450 11B1, mitochondrial(CYP11B1) detection. Tested with WB in Human. Background: CYP11B1(Cytochrome p450, family 11, subfamily B, polypeptide 1), also called Steroid 11-beta-hydroxylase or P450C11, is a steroid hydroxylase found in the zona fasciculata. The CYP11B1 gene functions primarily in mitochondria in the zona fasciculata of the adrenal cortex to convert 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone. CYP11B1 is a member of the cytochrome P450 superfamily of enzymes. It is mapped on 8q24.3. The CYP11B1 gene contains 9 exons and spans 6.5 kb. Using RT-PCR, Kayes-Wandover and White detected CYP11B1 mRNA in human cardiac tissue samples from left and right atria, aorta, apex, intraventricular septum, and atrioventricular node, as well as whole adult and fetal heart. Ventricles did not express CYP11B1. In patients with 11-beta-hydroxylase deficiency leading to hypertension and congenital adrenal hyperplasia, Pascoe et al. identified mutations in the CYP11B1 gene.

NCBI GI登录号 :

215274267

NCBI登录号 :

P15538.5

UniProt数据库登录号 :

P15538

NCBI分子量 :

49,750 Da

NCBI信号通路 :

Biological Oxidations Pathway 105698!!C21-Steroid Hormone Biosynthesis, Progesterone = Corticosterone/aldosterone Pathway 413394!!C21-Steroid Hormone Biosynthesis, Progesterone = Corticosterone/aldosterone Pathway 468295!!C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway 413395!!C21-Steroid Hormone Biosynthesis, Progesterone = Cortisol/cortisone Pathway 468370!!Corticotropin-releasing Hormone Pathway 920957!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700!!Endogenous Sterols Pathway 105701!!Glucocorticoid Biosynthesis Pathway 106152!!Metabolic Pathways 132956

NCBI总结 :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

规格 :

0.1毫克

价格 :

245美元

更多信息或购买 :

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公司信息