抗体

FSHR多克隆抗体

MBS128093

0.05毫升

230美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

抗体

FSHR多克隆抗体

FSHR

FSHR;FSHRO;LGR1;MGC141667;MGC141668;ODG1

卵泡刺激素受体;卵泡刺激素受体;卵泡刺激素受体;卵泡刺激素受体;卵泡刺激素受体;卵泡刺激素受体;卵泡刺激素受体

FSHR

FSHR;FSHR;LGR1;ODG1;FSHRO;LGR1;FSH-R

FSHR_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

695

亲和纯化

1毫克/毫升

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

免疫印迹(免疫印迹), 免疫组化(免疫组化)

WB: 1:500 - 1:2000。 IHC: 1:50 - 1:200

Species: Human. Immunogen: Recombinant Protein

Immunogen: Recombinant protein of human FSHR. Calculated Molecular Weight: 78kDa

多克隆

FSHR, also named as LGR1, belongs to the G-protein coupled receptor 1 family and FSH/LSH/TSH subfamily. FSHR is a receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). The antibody is special to FSHR.

311033420

P23945.3

P23945

695

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); FSH Signaling Pathway (672455); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Hormone Ligand-binding Receptors Pathway (106369)

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2p21-p16. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; follicle-stimulating hormone receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; gonad development; follicle-stimulating hormone signaling pathway; male gonad development; female gamete generation; spermatogenesis; female gonad development. Disease: Ovarian Hyperstimulation Syndrome; Twinning, Dizygotic; Ovarian Dysgenesis 1

0.05毫升

230美元

0.1毫升

305

0.2毫升

460