cDNA

TNNT2 cDNA克隆

MBS1278333

0.01毫克质粒+0

165美元

cDNA克隆

TNNT2 cDNA克隆

TNNT2

Homo sapiens troponin T type 2 (cardiac), mRNA; Troponin T, cardiac muscle; troponin T, cardiac muscle; troponin T2, cardiac type; Cardiac muscle troponin T; cTnT

TNNT2

TNNT2; TNNT2; CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6; TnTc; cTnT

TNNT2_HUMAN

1125

atgtctgacatagaagaggtggtggaagagtacgaggag
gaggagcaggaagaagcagctgttgaagagcaggaggag
gcagcggaagaggatgctgaagcagaggctgagaccgag
gagaccagggcagaagaagatgaagaagaagaggaagca
aaggaggctgaagatggcccaatggaggagtccaaacca
aagcccaggtcgttcatgcccaacttggtgcctcccaag
atccccgatggagagagagtggactttgatgacatccac
cggaagcgcatggagaaggacctgaatgagttgcaggcg
ctgatcgaggctcactttgagaacaggaagaaagaggag
gaggagctcgtttctctcaaagacaggatcgagagacgt
cgggcagagcgggccgagcagcagcgcatccggaatgag
cgggagaaggagcggcagaaccgcctggctgaagagagg
gctcgacgagaggaggaggagaacaggaggaaggctgag
gatgaggcccggaagaagaaggctttgtccaacatgatg
cattttgggggttacatccagaagacagagcggaaaagt
gggaagaggcagactgagcgggaaaagaagaagaagatt
ctggctgagaggaggaaggtgctggccattgaccacctg
aatgaagatcagctgagggagaaggccaaggagctgtgg
cagagcatctataacttggaggcagagaagttcgacctg
caggagaagttcaagcagcagaaatatgagatcaatgtt
ctccgaaacaggatcaacgataaccagaaagtctccaag
acccgcgggaaggctaaagtcaccgggcgctggaaatag

Vector: Please Inquire

33876979

BC002653

30,681 Da

Cardiac Progenitor Differentiation Pathway (712094); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262)

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: cytosol; sarcomere; striated muscle thin filament; troponin complex. Molecular Function: actin binding; protein binding; tropomyosin binding; troponin C binding; troponin I binding. Biological Process: muscle filament sliding; negative regulation of ATPase activity; positive regulation of ATPase activity; regulation of heart contraction; response to calcium ion; ventricular cardiac muscle morphogenesis. Disease: Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2; Cardiomyopathy, Familial Restrictive, 3

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

165美元