抗体

胰岛素样生长因子1受体多克隆抗体

MBS125631

0.05毫克

230美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

胰岛素样生长因子1受体多克隆抗体

胰岛素样生长因子1受体

IGF-I Receptor beta: IGF-I Receptor b; IGF1R; CD221; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216

Insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain

胰岛素样生长因子1受体

胰岛素样生长因子1受体;胰岛素样生长因子1受体;IGFR;CD221;IGFIR;JTK13;IGF-I受体

IGF1R_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

1367

亲和纯化

1毫克/毫升

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

免疫印迹(免疫印迹)

WB: 1:500 - 1:2000

Species: Human. Route: Synthetic Peptide

Immunogen: N term -peptide of human IGF1R. Calculated Molecular Weight: 155kDa

多克隆

IGF1R, also named as CD221, belongs to the protein kinase superfamily, Tyr protein kinase family and Insulin receptor subfamily. IGF1R binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, IGF1R binds IGF1. The hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, the hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance). The antibody is specific to IGF1R.

124240

P08069.1

P08069

1367

AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Apoptosis Pathway 198797!!Endochondral Ossification Pathway 198812!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

0.05毫克

230美元