产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
胰岛素样生长因子1受体多克隆抗体
目录 :
MBS125631
规格 :
0.05毫克
价格 :
230美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS125631
产品类型 :
抗体
产品全称 :
胰岛素样生长因子1受体多克隆抗体
产品简称 :
胰岛素样生长因子1受体
产品名称同义词 :
IGF-I Receptor beta: IGF-I Receptor b; IGF1R; CD221; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216
其他名称 :
Insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
产品基因名称 :
胰岛素样生长因子1受体
其他基因名称 :
胰岛素样生长因子1受体;胰岛素样生长因子1受体;IGFR;CD221;IGFIR;JTK13;IGF-I受体
UniProt数据库进入名 :
IGF1R_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
1367
纯度 :
亲和纯化
浓度 :
1毫克/毫升
储存稳定性 :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
WB: 1:500 - 1:2000
其它信息1 :
Species: Human. Route: Synthetic Peptide
其他信息2 :
Immunogen: N term -peptide of human IGF1R. Calculated Molecular Weight: 155kDa
产品种类 :
多克隆
产品描述 :
IGF1R, also named as CD221, belongs to the protein kinase superfamily, Tyr protein kinase family and Insulin receptor subfamily. IGF1R binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, IGF1R binds IGF1. The hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, the hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance). The antibody is specific to IGF1R.
NCBI GI登录号 :
124240
NCBI登录号 :
P08069.1
UniProt数据库登录号 :
P08069
NCBI分子量 :
1367
NCBI信号通路 :
AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Apoptosis Pathway 198797!!Endochondral Ossification Pathway 198812!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067
NCBI总结 :
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
规格 :
0.05毫克
价格 :
230美元
更多信息或购买 :
公司信息
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MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。
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