抗体

小鼠单克隆抗体抗人类ASH1L

MBS120006

0.1毫克

345美元

单克隆

小鼠

未共轭

ASH5H03

免疫印迹, dot blot

抗体

小鼠单克隆抗体抗人类ASH1L

ASH1L

ash1 (absent, small, or homeotic)-like (Drosophila)? (ASH1L); ASH1; ASH1L1; huASH1; FLJ10504; KIAA1420

Homo sapiens ash1 (absent, small, or homeotic)-like (Drosophila) (ASH1L), mRNA; Histone-lysine N-methyltransferase ASH1L; histone-lysine N-methyltransferase ASH1L; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N-methyltransferase 2H; probable histone-lysine N-methyltransferase ASH1L; ash1 (absent, small, or homeotic)-like (Drosophila); ASH1-like protein; huASH1; Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H

ASH1L

ASH1L;ASH1L;ASH1;KMT2H;ASH1L1

ASH1L_HUMAN

单克隆

IgG1

ASH5H03

小鼠

人类

11784

100微克/毫升(1.0毫升)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [NCBI Entrez Gene Summary]

110349787

NP_060959.2

NM_018489

332,211 Da

Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320); Tight Junction Pathway (83071); Tight Junction Pathway (482)

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

ASH1L: a protein methyltransferase that specifically methylates K36 of histone H3 (H3K36me). A member of the trithorax group (trxG) of transcriptional activators that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells. Widely expressed, with high levels in brain, heart and kidney. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Protein type: Methyltransferase; Methyltransferase, protein lysine; Cell adhesion; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: nucleoplasm; Golgi apparatus; tight junction; cytoplasm; chromosome; nucleus. Molecular Function: DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); chromatin binding. Biological Process: transcription from RNA polymerase II promoter; cell-cell signaling; interleukin-6 production; negative regulation of MAPKKK cascade; histone H3-K4 methylation; negative regulation of acute inflammatory response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of I-kappaB kinase/NF-kappaB cascade; DNA packaging

0.1毫克

345美元