产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
鸡A单链蛇毒多肽和金属蛋白酶10酶联免疫吸附试剂盒
目录 :
MBS041822
规格 :
96 Strip Wells
价格 :
600美元
更多信息或购买 :
产品信息
目录号 :
MBS041822
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
鸡A单链蛇毒多肽和金属蛋白酶10酶联免疫吸附试剂盒
产品简称 :
A单链蛇毒多肽和金属蛋白酶10
其他名称 :
ADAM10; Disintegrin and metalloproteinase domain-containing protein 10; disintegrin and metalloproteinase domain-containing protein 10; CDw156; ADAM 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10; ADAM metallopeptidase domain 10; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease
产品基因名称 :
ADAM10
其他基因名称 :
ADAM10; ADAM10; kuz; AD10; MADM; CD156c; HsT18717; KUZ; MADM; ADAM 10
UniProt数据库进入名 :
ADA10_HUMAN
反应物种 :
鸡
储存稳定性 :
Store all reagents at 2-8 degree C
其它信息1 :
ELISA Type: Sandwich
NCBI GI登录号 :
2393947
NCBI登录号 :
AAC51766.1
UniProt数据库登录号 :
O14672
NCBI分子量 :
84,142 Da
NCBI信号通路 :
Activated NOTCH1 Transmits Signal To The Nucleus Pathway 576270!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway 771591!!Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway 771595!!Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway 771593!!Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway 771589!!Degradation Of Collagen Pathway 730309!!Degradation Of The Extracellular Matrix Pathway 576263
NCBI总结 :
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. Ref.4 Ref.5 Ref.7 Ref.8 Ref.10 Ref.11 Ref.14 Ref.16. Catalytic activity: Endopeptidase of broad specificity. Cofactor: Binds 1 zinc ion . By similarity. Subunit structure: Interacts with EPHA2 . By similarity. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells. Ref.8. Subcellular location: Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Note: Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi. Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. Ref.3 Ref.6. Induction: In osteoarthritis affected-cartilage. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, it recognizes the EFNA5-EPHA3 Complex but not the individual proteins . By similarity. Post-translational modification: The precursor is cleaved by a furin endopeptidase . By similarity. Sequence similarities: Contains 1 disintegrin domain.Contains 1 peptidase M12B domain.
规格 :
96 Strip Wells
价格 :
600美元
更多信息或购买 :
公司信息
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MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。