产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
蛋白
产品名称 :
人类RUSC1合成肽
目录 :
PEP-0936
规格 :
50微克
价格 :
美国159.00
更多信息或购买 :
产品信息
产品类型 :
多肽
产品名称 :
人类RUSC1合成肽
目录# :
PEP-0936
规格 :
50微克
价格 :
美国159.00
克隆性 :
Synthetic
纯度 :
纯化
反应物种 :
人类
应用 :
Blocking Assay: Assay-dependent, Control: Assay-dependent
物种 :
人类
储存 :
-20°C
描述 :
RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Ikappa-B kinase- (IKK-) -gamma, the regulatory subunit of the IKK complex that is required for NF-kappa-B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappa-B activation pathway.
格式 :
液体
应用w/稀释 :
Blocking Assay: Assay-dependent, Control: Assay-dependent
别名 :
2210403N08Rik; AA408288; LOC100360417; Nesca; new molecule containing SH3 at the carboxy-terminus; RP11-21N7.4; RUN and SH3 domain containing 1; RUN and SH3 domain containing 1-like; RUN and SH3 domain-containing protein 1; RUSC1
更多信息或购买 :
公司信息
赛默飞世尔