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抗体

TAGLN2多克隆抗体

PA5-99987

100微升

美国446.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

TAGLN2多克隆抗体

PA5-99987

100微升

美国446.00

多克隆

亲和色谱

兔

人类, 小鼠, 大鼠

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

人类, 小鼠, 大鼠

IgG

-20°C

Transgelin (also designated SM22alpha), is expressed abundantly in smooth muscle cells. Transgelin-2 (also known as SM22alpha homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. The human transgelin-2 gene (designated TAGLN2), which is located on chromosome 1q231-q25, encodes a 199 amino acid protein that contains a calponin-like repeat and a calponin-homology (CH) domain. Transgelin-2 may function very similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds actin, causing actin fibers to gel within minutes of binding. Binding of transgelin to actin occurs at a ratio of 1:6 actin monomers.

A synthesized peptide derived from human TAGLN2(Accession P37802), corresponding to amino acid residues L129-G179.

液体

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

2700094C18Rik; CDABP0035; Epididymis tissue protein Li 7e; HA1756; Kiaa0120; Sm22a; SM22-alpha homolog; Sm22B; SM22beta; SM22-beta; Tagln2; transgelin 2; transgelin-2