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抗体

磷酸化Chk1(Ser317)多克隆抗体

PA5-99338

100微升

美国436.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

磷酸化Chk1(Ser317)多克隆抗体

PA5-99338

100微升

美国436.00

多克隆

sequential chromatography

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:2,000

人类, 小鼠, 大鼠

IgG

-20°C

CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.

A synthesized peptide derived from human CHEK1(Accession O14757), corresponding to amino acid residues around phosphorylated Ser317.

液体

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:2,000

C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W