产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
HLA-DRB4多克隆抗体
目录 :
PA5-87621
规格 :
100微升
价格 :
美国446.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
HLA-DRB4多克隆抗体
目录# :
PA5-87621
规格 :
100微升
价格 :
美国446.00
克隆性 :
多克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
Western Blot: 1:1,000-1:4,000
物种 :
人类, 小鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
免疫原 :
Recombinant fusion protein containing a sequence corresponding to amino acids 30-227 of human HLA-DRB4 (NP_0688184)
格式 :
液体
应用w/稀释 :
Western Blot: 1:1,000-1:4,000
别名 :
DR4; DR-4; DRB1 transplantation antigen; DRB4; HLA class II histocompatibility antigen, DR beta 4 chain; HLA-DR4B; HLA-DRB4; human leucocyte antigen DRB4; leukocyte antigen; major histocompatibility complex, class II, DR beta 4; MHC class II antigen DRB4; MHC class II antigen HLA-DR-beta; MHC class2 antigen; MHC HLA DR-beta chain
更多信息或购买 :
公司信息
赛默飞世尔