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抗体

RARA多克隆抗体

PA5-87426

100微升

美国446.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学

RARA多克隆抗体

PA5-87426

100微升

美国446.00

多克隆

亲和色谱

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 1:50-1:100, Western Blot: 1:500-1:2,000

人类, 小鼠, 大鼠

IgG

-20° C, 避免反复冷冻/解冻

RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

Recombinant fusion protein containing a sequence corresponding to amino acids 1-457 of human RARα (NP_0010199801)

液体

Immunocytochemistry: 1:50-1:100, Western Blot: 1:500-1:2,000

Nr1b1; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR; RAR Alpha; RAR alpha 1; RARA; RAR-alpha; RARalpha1; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; retinoic acid receptor alpha; retinoic acid receptor, alpha; retinoic acid receptor, alpha polypeptide; RRA