产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
WISP1多克隆抗体
目录 :
PA5-80228
规格 :
100微克
价格 :
美国395.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
WISP1多克隆抗体
目录# :
PA5-80228
规格 :
100微克
价格 :
美国395.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunohistochemistry (Frozen): 0.5-1 µg/mL, Immunohistochemistry (Paraffin): 2-5 ug/ml, Western Blot: 0.1-0.5 µg/mL
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.
免疫原 :
A synthetic peptide corresponding to a sequence at the C-terminus of human WISP1 (354-367aa ADLESYPDFSEIAN).
格式 :
冻干
应用w/稀释 :
Immunohistochemistry (Frozen): 0.5-1 µg/mL, Immunohistochemistry (Paraffin): 2-5 ug/ml, Western Blot: 0.1-0.5 µg/mL
别名 :
AW146261; CCN family member 4; Ccn4; CTC-458A3.8; Elm1; ELM-1; WISP1; WISP-1; WISP1c; WISP1i; WISP1tc; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; Wnt-1 inducible signaling pathway protein 1; Wnt-1-induced secreted protein; WNT1-inducible-signaling pathway protein 1
更多信息或购买 :
公司信息
赛默飞世尔