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抗体

DUT多克隆抗体

PA5-79175

100微克

美国389.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

DUT多克隆抗体

PA5-79175

100微克

美国389.00

多克隆

抗原亲和色谱

兔

人类, 小鼠, 大鼠

Immunohistochemistry (Paraffin): 0.5-1 µg/mL, Western Blot: 0.1-0.5 µg/mL

人类, 小鼠, 大鼠

IgG

-20°C

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

A synthetic peptide corresponding to a sequence at the C-terminus of human DUT (212-229aa KKGDRIAQLICERIFYPE).

冻干

Immunohistochemistry (Paraffin): 0.5-1 µg/mL, Western Blot: 0.1-0.5 µg/mL

5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Deoxyuridine 5'-triphosphate nucleotidohydrolase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; deoxyuridine triphosphatase; Dut; Dutp; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622; PIP4; PPAR-interacting protein 4