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抗体

磷酸化MKNK2(Thr249)多克隆抗体

PA5-64594

100微升

美国446.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

磷酸化MKNK2(Thr249)多克隆抗体

PA5-64594

100微升

美国446.00

多克隆

亲和色谱

兔

人类, 小鼠, 大鼠

Western Blot: 1:1,000

人类, 小鼠, 大鼠

IgG

-20°C

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis. Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta.

A synthesized peptide derived from human MNK2 (Phospho-Thr249).

液体

Western Blot: 1:1,000

2010016G11Rik; G protein-coupled receptor kinase 7; GPRK7; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2; MAPK interacting serine/threonine kinase 2; MAPK signal-integrating kinase 2; Mknk2; MNK2