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抗体

WISP2多克隆抗体

PA5-49693

100微升

美国446.00

多克隆

domestic rabbit

未共轭

WISP2多克隆抗体

PA5-49693

100微升

美国446.00

多克隆

亲和色谱

兔

人类

Western Blot: 1:500-1:1,000

人类

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Peptide sequence around aa.242~246(G-R-S-P-Q) derived from Human WISP2.

液体

Western Blot: 1:500-1:1,000

CCN family member 5; CCN family protein COP-1; Ccn5; connective tissue growth factor-like protein; Connective tissue growth factor-related protein 58; Cop1; Crgr4; CT58; CTGFL; CTGF-L; Rcop1; UNQ228/PRO261; WISP2; WISP-2; WNT1 inducible signaling pathway protein 2; WNT1-inducible-signaling pathway protein 2