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抗体

ORC1多克隆抗体

PA5-23390

100微克

美国450.00

多克隆

domestic rabbit

未共轭

人类, 小鼠

ORC1多克隆抗体

PA5-23390

100微克

美国450.00

多克隆

蛋白质A

兔

人类, 小鼠

Western Blot: 1-3 µg/mL

人类, 小鼠

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.

A portion of amino acids 170 to 220 of human ORC1L

液体

Western Blot: 1-3 µg/mL

AA545195; HS; HSORC1; MmORC1; orc1; orc1.L; Orc1l; origin recognition complex protein 1; origin recognition complex subunit 1; origin recognition complex subunit 1 L homeolog; origin recognition complex, subunit 1; origin recognition complex, subunit 1 homolog; origin recognition complex, subunit 1-like; PARC1; Replication control protein 1; XELAEV_18023178mg; xorc1