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抗体

TXK多克隆抗体

PA5-14797

400微升

美国456.00

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫组化, 免疫组化-石蜡切片

TXK多克隆抗体

PA5-14797

400微升

美国456.00

多克隆

Ammonium sulfate precipitation, Size-exclusion - Dialysis

兔

人类

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:2,000

人类

IgG

-20° C, 避免反复冷冻/解冻

TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

KLH conjugated synthetic peptide between 22-52 amino acids from the N-terminal region of human TXK

液体

Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:2,000

A130089B16Rik; BTKL; Protein-tyrosine kinase 4; PSCTK5; PTK4; PTK4 protein tyrosine kinase 4; PTK-RL-18; resting lymphocyte kinase; Rlk; TKL; TXK; TXK tyrosine kinase; tyrosine kinase; tyrosine-protein kinase TXK