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抗体

Bi-1 Polyclonal Antibody

PA5-143940

100微克

美国379.00

多克隆

domestic rabbit

未共轭

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

Bi-1 Polyclonal Antibody

PA5-143940

100微克

美国379.00

多克隆

抗原亲和色谱

兔

人类

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 2-5 µg/mL, Western Blot: 0.25-0.5 µg/mL

人类

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.

A合成多肽对应于a序列人的BI-1/TMBIM6(RKINFDALLKFSHITPSTQQHLK)

冻干

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 2-5 µg/mL, Western Blot: 0.25-0.5 µg/mL

5031406P05Rik; Ab1-011; Ac1-149; Bax inhibitor 1; Bax inhibitor-1; BAXI1; Bi1; BI-1; Cc1-27; Tegt; testis enhanced gene transcript; testis-enhanced gene transcript protein; Tmbim6; transmembrane BAX inhibitor motif containing 6; transmembrane BAX inhibitor motif-containing protein 6