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抗体

EWSR1多克隆抗体, 生物素

PA5-142450

100微克

美国426.00

多克隆

domestic goat

生物素

EWSR1多克隆抗体, 生物素

PA5-142450

100微克

美国426.00

多克隆

硫酸铵沉淀

山羊

人类

Western Blot: 0.3-1 µg/mL

人类

IgG

-20° C, 避免反复冷冻/解冻

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a ttranslocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Peptide with sequence C-TSYDQSSYSQQNTYG.

液体

Western Blot: 0.3-1 µg/mL

AC002059.7; bK984G1.4; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 protein; Ewing sarcoma homolog; Ewings sarcoma EWS-Fli1 (type 1) oncogene; Ews; EWS oncogene; EWS RNA binding protein 1; EWS RNA-binding protein 1; EWS RNA-binding protein variant 6; EWS-FLI1; Ewsh; EWSR1; RNA-binding protein EWS