NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

MYH9多克隆抗体

PA5-120506

100微升

美国440.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

MYH9多克隆抗体

PA5-120506

100微升

美国440.00

多克隆

亲和色谱

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:100-1:500

人类, 小鼠, 大鼠

IgG

-20° C, 避免反复冷冻/解冻

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.

Recombinant fusion protein containing a sequence corresponding to amino acids 1801-1960 of human MYH9 (NP_002464.1).

液体

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:100-1:500

BDPLT6; Cellular myosin heavy chain, type A; DFNA17; epsts; fi22c04; fj85e11; flectin; Fltn; FTNS; KLG/PTK7; LOC100911597; LOW QUALITY PROTEIN: myosin-9; MGC104539; MHA; Myh9; myh9.L; myh9a; myh9l2; Myhn1; Myhn-1; myosin; Myosin Heavy Chain 2A; myosin heavy chain 9; myosin heavy chain IX; myosin heavy chain, non-muscle IIa; myosin IIA; myosin, heavy chain 9, non-muscle; myosin, heavy chain 9, non-muscle L homeolog; myosin, heavy chain 9, non-muscle, like-2; myosin, heavy chain 9a, non-muscle; myosin, heavy polypeptide 9, non-muscle; myosin, heavy polypeptide 9a, non-muscle; myosin-2a; myosin9; Myosin-9; myosin-9; myosin-9a; myosin-9-like; NMHC II-A; NMHC-II A; NMHCIIA; NMHC-II-A; NMMHC IIA; NMMHC II-a; nmmhca; NMMHC-A; NMMHC-IIA; non-muscle myosin heavy chain 9; non-muscle myosin heavy chain A; non-muscle myosin heavy chain II A; non-muscle myosin heavy chain IIa; nonmuscle myosin heavy chain II-A; non-muscle myosin heavy polypeptide 9; nonmuscle myosin II heavy chain A; TU72.6; Unknown (protein for IMAGE:7151033); Unknown (protein for IMAGE:7177375); Unknown (protein for IMAGE:7268224); wu:fi22c04; wu:fi22c04 protein; wu:fj85e11; XELAEV_18023533mg; zgc:162029; zgc:66164; zNMHC-IIA