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抗体

磷酸化ASK1(Thr838)多克隆抗体

PA5-118633

100微升

美国416.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

磷酸化ASK1(Thr838)多克隆抗体

PA5-118633

100微升

美国416.00

多克隆

sequential chromatography

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:3,000

人类, 小鼠, 大鼠

IgG

-20°C

MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.

A synthesized peptide derived from human MAP3K5(Accession Q99683), corresponding to amino acid residues around phosphorylated Thr838.

液体

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:3,000

7420452D20Rik;凋亡信号调节激酶1;凋亡信号调节激酶1;ASK;ASK 1;ASK1;ASK-1;EC 2.7。 11.25;激酶ASK1;M3K5;地图/ERK激酶激酶5;Map3k5;MAPK/ERK激酶激酶5;mapkkk;MEK激酶5;MEKK 5;Mekk5;丝裂原活化蛋白激酶激酶激酶 5;丝裂原活化蛋白激酶激酶激酶 5;RGD1306565;RP3-325F22.4