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抗体

Phospho-Rb (Thr373) Polyclonal Antibody

PA5-106106

100微升

美国446.00

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫细胞化学

Phospho-Rb (Thr373) Polyclonal Antibody

PA5-106106

100微升

美国446.00

多克隆

sequential chromatography

兔

人类, 小鼠, 大鼠

Immunocytochemistry: 1:100-1:500, Western Blot: 1:1,000-1:3,000

人类, 小鼠, 大鼠

IgG

-20°C

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

A synthesized peptide derived from human RB1(Accession P06400), corresponding to amino acid residues around phosphorylated Thr373.

液体

Immunocytochemistry: 1:100-1:500, Western Blot: 1:1,000-1:3,000

Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p104; p104 chicken Rb; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma 1 (including osteosarcoma); retinoblastoma 1 protein; retinoblastoma gene; retinoblastoma isoform A; retinoblastoma protein; retinoblastoma suspectibility protein; retinoblastoma tumor suppressor; retinoblastoma-associated protein