产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
糖皮质激素受体乙多克隆抗体
目录 :
PA3-514
规格 :
50微升
价格 :
美国430.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 6
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图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
糖皮质激素受体乙多克隆抗体
目录# :
PA3-514
规格 :
50微升
价格 :
美国430.00
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类
应用 :
Immunocytochemistry: 1:1,500, Immunoprecipitation: Assay-dependent, Western Blot: 1:500
物种 :
人类
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism, and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocorticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that the alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform has been observed to translocate from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR beta might function as a dominant negative inhibitor of GR alpha activity.
免疫原 :
Synthetic Peptide: N(728) V M W L K P E S T S H T L I(742) C
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:1,500, Immunoprecipitation: Assay-dependent, Western Blot: 1:500
别名 :
GCCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; GR; GR Beta; GRL; NR3C1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
更多信息或购买 :
公司信息
赛默飞世尔