产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PSMD1多克隆抗体
目录 :
PA1-973
规格 :
100微克
价格 :
美国471.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
文章摘录数: 2
| 参考文献 |
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Patil H, Yoon D, Bhowmick R, Cai Y, Cho K, Ferreira P. Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I . Small Gtpases. 2019;10:146-161 pubmed 出版商
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图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
PSMD1多克隆抗体
目录# :
PA1-973
规格 :
100微克
价格 :
美国471.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
Bovine, Human, Mouse, Non-human primate, Rat
应用 :
Immunohistochemistry: 15 µg/mL, Western Blot: 0.5-2 µg/mL
物种 :
Bovine, Human, Mouse, Non-human primate, Rat
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
免疫原 :
Synthetic Peptide: A(929) A H G P K I E E E E Q E P E P P E P F E Y I D D(953)
格式 :
液体
应用w/稀释 :
Immunohistochemistry: 15 µg/mL, Western Blot: 0.5-2 µg/mL
别名 :
2410026J11Rik; 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome p112 subunit; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112; 26S proteasome, subunit p112; MGC133040; MGC133041; P112; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; proteasome 26S non-ATPase subunit 1; proteasome 26S subunit, non-ATPase 1; Psmd1; Rpn2; S1
更多信息或购买 :
公司信息
赛默飞世尔