产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IP3受体2多克隆抗体
目录 :
PA1-904
规格 :
100微升
价格 :
美国430.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫组化, 免疫细胞化学, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 3
| 参考文献 |
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Balghi H, Sebille S, Mondin L, Cantereau A, Constantin B, Raymond G, et al. Mini-dystrophin expression down-regulates IP3-mediated calcium release events in resting dystrophin-deficient muscle cells. J Gen Physiol. 2006;128:219-30 pubmed
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Balghi H, Sebille S, Constantin B, Patri S, Thoreau V, Mondin L, et al. Mini-dystrophin expression down-regulates overactivation of G protein-mediated IP3 signaling pathway in dystrophin-deficient muscle cells. J Gen Physiol. 2006;127:171-82 pubmed
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Clapp T, Stone L, Margolskee R, Kinnamon S. Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci. 2001;2:6 pubmed
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图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
IP3受体2多克隆抗体
目录# :
PA1-904
规格 :
100微升
价格 :
美国430.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:100
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to IP3R, IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.
免疫原 :
Synthetic Peptide: E(317) L N P D Y R D A Q N E G K T V R D(334).
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:100
别名 :
AI649341; ANHD; CFAP48; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor 5; inositol 1,4,5-triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; inositol 1,4,5-trisphosphate receptor, type 2; inositol 1,4,5-trisphosphate type V receptor; inositol triphosphate receptor type 2; inositol trisphosphate receptor type 2; insP3R2; InsP3R-2; InsP3R-5; IP3 receptor; IP3 receptor isoform 2; IP3 receptor/Ca2+ channel type 2; IP3R; IP3R 2; IP3R2; Itpr2; Itpr5; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2; si:dkey-196d8.1; Type 2 inositol 1,4,5-trisphosphate receptor; type 2 InsP3 receptor
更多信息或购买 :
公司信息
赛默飞世尔