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抗体

Cortactin Polyclonal Antibody

PA1-9030

100微克

美国446.00

多克隆

domestic goat

未共轭

人类, 小鼠, 大鼠

Cortactin Polyclonal Antibody

PA1-9030

100微克

美国446.00

多克隆

硫酸铵沉淀

山羊

人类, 小鼠, 大鼠

Western Blot: 0.01-0.03 µg/mL

人类, 小鼠, 大鼠

IgG

-20° C, 避免反复冷冻/解冻

Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.

合成多肽对应于N末端氨基酸WKASAGHAVSIA

液体

Western Blot: 0.01-0.03 µg/mL

1110020L01Rik; amplaxin; cortactin; Cttn; Cttnb; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); FLJ34459; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); oncogene EMS1; Oncogene SRC8; Src substrate cortactin; src8; Unknown (protein for MGC:137923)