产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
糖皮质激素受体多克隆抗体
目录 :
PA1-510A
规格 :
200微升
价格 :
美国450.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 2
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图像
图像 1 :
Immunofluorescent analysis of Glucocorticoid Receptor using Glucocorticoid Receptor Polyclonal Antibody (Product# PA1-510A ) shows staining in A2058 Cells. Glucocorticoid Receptor (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with an antibody recognizing Glucocorticoid Receptor (Product# PA1-510A ) at a dilution of 1:100 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
图像 2 :
Immunolocalization of GR in human lymphocytes using Glucocorticoid Receptor Polyclonal Antibody (Product # PA1-510A).
产品信息
产品类型 :
抗体
产品名称 :
糖皮质激素受体多克隆抗体
目录# :
PA1-510A
规格 :
200微升
价格 :
美国450.00
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠, 爬行类动物
应用 :
Gel Shift: Assay-dependent, Immunocytochemistry: 1:250, Immunohistochemistry: 1:250, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:2,500
物种 :
人类, 小鼠, 大鼠, 爬行类动物
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity
免疫原 :
Synthetic Peptide: A(150) P T E K E F P K T H S D V S S E Q Q H L K G Q T G(175)
格式 :
液体
应用w/稀释 :
Gel Shift: Assay-dependent, Immunocytochemistry: 1:250, Immunohistochemistry: 1:250, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:2,500
别名 :
cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038
更多信息或购买 :
公司信息
赛默飞世尔