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抗体

SATB2重组兔单克隆抗体(PD01-42)

MA5-50745

100微升

美国439.00

重组

domestic rabbit

未共轭

PD01-42

免疫组化, 免疫组化-石蜡切片

SATB2重组兔单克隆抗体(PD01-42)

MA5-50745

100微升

美国439.00

重组单克隆

蛋白质A

兔

人类

免疫组化(石蜡): 1:1, 000

人类

PD01-42

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).

Synthetic peptide within C terminal human SATB2 aa 680-733/733.

液体

免疫组化(石蜡): 1:1, 000

DNA-binding protein SATB2; FLJ21474; FLJ32076; GLSS; KIAA1034; KIAA1034-like DNA binding protein; MGC119474; MGC119477; mKIAA1034; RGD1562369; SATB family member 2; SATB homeobox 2; SATB2; special AT-rich sequence binding protein 2; special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein