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抗体

FIS1重组兔单克隆抗体(27B4)

MA5-50014

100微升

美国389.00

重组

domestic rabbit

未共轭

27B4

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫组化-石蜡切片

FIS1重组兔单克隆抗体(27B4)

MA5-50014

100微升

美国389.00

重组单克隆

亲和色谱

兔

人类

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

人类

27B4

IgG

-20°C or -80°C if preferred

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

A synthesized peptide derived from human FIS1

液体

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

2010003O14Rik; CGI-135; Fis1; fis1 {ECO:0000250; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); fission 1 (mitochondrial outer membrane) homolog (yeast); fission, mitochondrial 1; H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; mitochondrial fission molecule; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11; UniProtKB:Q9Y3D6}