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抗体

RANKL重组大鼠单克隆抗体(IK22-5)

MA5-48185

200微克

美国489.00

重组

大鼠

未共轭

IK22-5

免疫组化, 中和反应, 流式细胞仪

RANKL重组大鼠单克隆抗体(IK22-5)

MA5-48185

200微克

美国489.00

重组单克隆

亲和色谱

大鼠

小鼠

Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Neutralization: Assay-dependent

小鼠

IK22-5

IgG2a, kappa

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Thus antibody was raised by immunising an SD rat with murine RANKL-transfected baby hamster kidney cells.

液体

Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Neutralization: Assay-dependent

CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine