NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

酪氨酸羟化酶单克隆抗体(4H2)

MA5-47336

500微升

美国1556.00

单克隆

小鼠

未共轭

4H2

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

酪氨酸羟化酶单克隆抗体(4H2)

MA5-47336

500微升

美国1556.00

单克隆

蛋白质A/G

小鼠

人类, 小鼠, 大鼠

Immunocytochemistry: 1:1,000, Immunohistochemistry (PFA fixed): 1:1,000, Western Blot: 1:1,000-1:2,000

人类, 小鼠, 大鼠

4H2

IgG1

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Full length human TH as expressed in and purified from E. coli

液体

Immunocytochemistry: 1:1,000, Immunohistochemistry (PFA fixed): 1:1,000, Western Blot: 1:1,000-1:2,000

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase