NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

MECP2单克隆抗体(4F11)

MA5-47334

500微升

美国1556.00

单克隆

小鼠

未共轭

4F11

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

MECP2单克隆抗体(4F11)

MA5-47334

500微升

美国1556.00

单克隆

蛋白质A/G

小鼠

人类, 小鼠, 大鼠

Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (PFA fixed): 1:1,000-1:5,000, Western Blot: 1:5,000-1:10,000

人类, 小鼠, 大鼠

4F11

IgG1

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Full length human recombinant MeCP2 expressed in and purified from E. coli.

液体

Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (PFA fixed): 1:1,000-1:5,000, Western Blot: 1:5,000-1:10,000

1500041B07Rik; AUTSX3; D630021H01Rik; DKFZp686A24160; Mbd5; MECP2; MeCp-2 protein; methyl CpG binding protein 2; methyl-CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a; WBP10