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抗体

GRP94单克隆抗体(9G10), 异硫氰酸荧光素

MA5-45097

200微克

美国416.00

单克隆

大鼠

异硫氰酸荧光素

9G10

豚鼠, 中国人仓鼠, 人类, 小鼠, 大鼠, 犬, 鸡, 牛, pigs , 家羊, 非洲爪蛙, domestic rabbit, 国内马

免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪

GRP94单克隆抗体(9G10), 异硫氰酸荧光素

MA5-45097

200微克

美国416.00

单克隆

蛋白质G

大鼠

Bovine, Canine, Chicken, Equine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat, Xenopus laevis

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000

Bovine, Canine, Chicken, Equine, Guinea Pig, Hamster, Human, Mouse, Non-human primate, Ovine, Porcine, Rabbit, Rat, Xenopus laevis

9G10

IgG2a

4° C, store in dark

GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.

Purified Grp94 isolated from chicken oviducts

液体

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000

108K heat shock protein; 108K HSP; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250; 98 kDa protein kinase; ecgp; endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250; endoplasmin-like protein; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; ERp99; glucose-regulated protein; glucose-regulated protein GRP94; glucose-regulated protein GRP94 precursor; GP96; gp96 homolog; gp96/GRP94; GRP94; GRP-94; heat shock 108 kDa protein; heat shock protein 108; heat shock protein 108.; heat shock protein 90 beta family member 1; heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta family member 1 L homeolog; heat shock protein 90kDa beta, member 1; heat shock protein gp96; HEL35; HEL-S-125m; HSP 108; hsp108; HSP90 beta; hsp90b1; hsp90b1 {ECO:0000250; hsp90b1.L; Polymorphic tumor rejection antigen 1; PPK 98; Ppk 98; a protein kinase; ppk98; stress-inducible tumor rejection antigen gp96; TA-3; Targ2; tra1; Tra-1; transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen; tumor rejection antigen (gp96) 1; tumor rejection antigen 1; Tumor rejection antigen gp96; UniProtKB:P08113}; XELAEV_18017384mg