产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
MACC1重组兔单克隆抗体(BLR135H)
目录 :
MA5-44458
规格 :
10微升
价格 :
美国135.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
BLR135H
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
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产品信息
产品类型 :
抗体
产品名称 :
MACC1重组兔单克隆抗体(BLR135H)
目录# :
MA5-44458
规格 :
10微升
价格 :
美国135.00
克隆性 :
重组单克隆
纯度 :
纯化
宿主 :
兔
反应物种 :
人类
应用 :
Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:100-1:500, Immunoprecipitation: 20 µL/1 mg lysate, Western Blot: 1:1,000
物种 :
人类
克隆 :
BLR135H
抗体亚型 :
IgG
储存 :
2-8°C
描述 :
MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
免疫原 :
Between 100 And 150
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:100-1:500, Immunoprecipitation: 20 µL/1 mg lysate, Western Blot: 1:1,000
别名 :
4732474O15Rik; 7A5; Gm267; MACC1; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; putative binding protein 7a5; RGD1309838; SH3 domain-containing protein 7a5; SH3BP4L
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公司信息
赛默飞世尔