产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
WAVE2重组兔单克隆抗体(7A6C10)
目录 :
MA5-42713
规格 :
100微升
价格 :
美国440.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
7A6C10
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
WAVE2重组兔单克隆抗体(7A6C10)
目录# :
MA5-42713
规格 :
100微升
价格 :
美国440.00
克隆性 :
重组单克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000
物种 :
人类, 小鼠, 大鼠
克隆 :
7A6C10
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
免疫原 :
A synthetic peptide corresponding to a sequence within amino acids 399-498 of human WAVE2/WASF2 (Q9Y6W5).
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000
别名 :
AW742646; D4Ertd13e; dJ393P12.2; IMD2; protein WAVE-2; putative Wiskott-Aldrich syndrome protein family member 4; SCAR2; suppressor of cyclic-AMP receptor (WASP-family); verprolin homology domain-containing protein 2; WAS protein family member 2; WAS protein family, member 2; Wasf2; WASF4; WASP family protein member 2; WASP family protein member 4; WASP family Verprolin-homologous protein 2; WAVE2; Wiskott-Aldrich syndrome protein family member 2
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公司信息
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赛默飞世尔