NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

5-hydroxymethylcytosine Monoclonal Antibody (DTA1002)

MA5-38433

100微克

美国446.00

单克隆

小鼠

未共轭

DTA1002

酶联免疫吸附测定, dot blot

5-hydroxymethylcytosine Monoclonal Antibody (DTA1002)

MA5-38433

100微克

美国446.00

单克隆

亲和色谱

小鼠

化学品

Dot Blot: 2 µg/mL, ELISA: 1:500, Methylated DNA Immunoprecipitation: 2.5 µg

化学品

DTA1002

IgG1, kappa

-20°C or -80°C if preferred

5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.

5-Hydroxymethylcytosine nucleotide

液体

Dot Blot: 2 µg/mL, ELISA: 1:500, Methylated DNA Immunoprecipitation: 2.5 µg

5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2