产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12), APC
目录 :
MA5-37401
规格 :
10试验
价格 :
美国185.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
APC
克隆名称 :
AuroraABC-CC12
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
Phospho-Aurora A/B/C (Thr288, Thr232, Thr198) Recombinant Rabbit Monoclonal Antibody (AuroraABC-CC12), APC
目录# :
MA5-37401
规格 :
10试验
价格 :
美国185.00
克隆性 :
重组单克隆
纯度 :
蛋白质A/G
宿主 :
兔
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL/1x10^6 cells
物种 :
人类
克隆 :
AuroraABC-CC12
抗体亚型 :
IgG, kappa
储存 :
4° C
描述 :
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes.
免疫原 :
A synthetic phospho-peptide corresponding to residues surrounding human Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL/1x10^6 cells
别名 :
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase Ayk1; STK1; STK-1; Stk12; Stk15; Stk5; STK6; STK7
更多信息或购买 :
公司信息
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赛默飞世尔