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抗体

BDNF单克隆抗体(3R7D0)

MA5-34960

100微升

美国436.00

单克隆

小鼠

未共轭

3R7D0

小鼠, 大鼠

BDNF单克隆抗体(3R7D0)

MA5-34960

100微升

美国436.00

单克隆

亲和色谱

小鼠

小鼠, 大鼠

Western Blot: 1:2,000-1:10,000

小鼠, 大鼠

3R7D0

IgG2a, kappa

-20° C, 避免反复冷冻/解冻

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

Recombinant fusion protein containing a sequence corresponding to amino acids 20-247 of human BDNF (P23560)

液体

Western Blot: 1:2,000-1:10,000

abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF