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抗体

磷酸化信号传导子及转录激活子1(Ser727)重组兔单克隆抗体(Stat1S727-C6), 异硫氰酸荧光素

MA5-28057

100试验

美国421.00

重组

domestic rabbit

异硫氰酸荧光素

Stat1S727-C6

磷酸化信号传导子及转录激活子1(Ser727)重组兔单克隆抗体(Stat1S727-C6), 异硫氰酸荧光素

MA5-28057

100试验

美国421.00

重组单克隆

蛋白质A/G

兔

人类

Flow Cytometry: 5 µL/1x10^6 cells

人类

Stat1S727-C6

IgG, kappa

4° C, store in dark

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

A synthetic phospho-peptide corresponding to residues surrounding Ser727 of human phospho Stat1.

液体

Flow Cytometry: 5 µL/1x10^6 cells

2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84