产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
HSF1单克隆抗体(10H8)
目录 :
MA5-27688
规格 :
100微克
价格 :
美国476.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
10H8
反应物种 :
豚鼠, 中国人仓鼠, 人类, 小鼠, 大鼠, 牛, domestic rabbit, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀
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文章摘录数: 1
产品信息
产品类型 :
抗体
产品名称 :
HSF1单克隆抗体(10H8)
目录# :
MA5-27688
规格 :
100微克
价格 :
美国476.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
大鼠
反应物种 :
牛, 豚鼠, 仓鼠, 人类, 小鼠, 兔, 大鼠, 猕猴
应用 :
ELISA: Assay-Dependent, Gel Shift: Assay-dependent, Immunocytochemistry: 1:200, Immunohistochemistry (PFA fixed): 1:1,000, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
物种 :
牛, 豚鼠, 仓鼠, 人类, 小鼠, 兔, 大鼠, 猕猴
克隆 :
10H8
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
All organisms respond to elevated temperatures and a variety of environmental stresses by rapid synthesis of heat shock RNAs and proteins. The regulation of heat shock gene transcription is mediated by the transcriptional activator, heat shock factor (HSF), which binds to heat shock response elements (HSEs). These HSEs are found as three repeats of a 5-nucleotide {nGAAn} module, arranged in alternating orientation and present upstream of all heat shock genes. The HSEs are highly conserved among species yet HSF purified from yeast, Drosophila and human have different molecular weights and the proteins do not show significant immunological cross reaction. Two HSFs have been identified in human cells, HSF1 and HSF2, which bind to the same HSEs and have 38% sequence identity. These factors are activated by distinct stimuli, HSF1 is responsive to classical stress signals such as heat, heavy metals and oxidative reagents, whereas HSF2 is activated during hemin-mediated differentiation of human erythroleukemia cells. HSF1 exists constitutively in the cytoplasm and the nucleus of unstressed cells as a monomer which lacks DNA binding activity. Through an unknown signal generated during stress, HSF1 becomes activated to a nuclear localized, trimeric state which binds to DNA. The phosphorylation of HSF1 is necessary for maximal transcription of heat shock genes.
免疫原 :
Purified recombinant mouse HSF1 protein, with epitope mapping to amino acids 378-395
格式 :
液体
应用w/稀释 :
ELISA: Assay-Dependent, Gel Shift: Assay-dependent, Immunocytochemistry: 1:200, Immunohistochemistry (PFA fixed): 1:1,000, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
别名 :
AA960185; heat shock factor 1; heat shock factor 2; Heat shock factor protein 1; Heat shock transcription factor 1; heat shock transcription factor 1 alpha isoform; heat shock transcription factor 1 beta isoform; heat shock transcription factor 1 gammaalpha isoform; heat shock transcription factor 1 gammabeta isoform; HSF; HSF 1; Hsf1; Hsf1alpha; Hsf1beta; Hsf1gammaalpha; Hsf1gammabeta; HSTF 1; HSTF1
更多信息或购买 :
公司信息
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赛默飞世尔