产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
胰岛素受体底物1单克隆抗体(J.566.7)
目录 :
MA5-15072
规格 :
100µL
价格 :
美国345
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
J.566.7
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
更多信息或购买 :
图像
图像 1 :
![赛默飞世尔 MA5-15072 图像 1](http://www.labome.com/product/Invitrogen/2228901_0.jpg)
产品信息
产品类型 :
抗体
产品名称 :
胰岛素受体底物1单克隆抗体(J.566.7)
目录# :
MA5-15072
规格 :
100µL
价格 :
美国345
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
Human, Mouse, Non-human primate, Rat
应用 :
Western Blot: 1:1000
物种 :
Human, Mouse, Non-human primate, Rat
克隆 :
J.566.7
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
免疫原 :
Synthetic peptide corresponding to the sequence surrounding Ser612 of human IRS-1
格式 :
液体
应用w/稀释 :
Western Blot: 1:1000
别名 :
G972R; HIRS-1; Insulin receptor substrate 1; IRS1; Irs-1; IRS1IRM; pp185
更多信息或购买 :
公司信息
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赛默飞世尔