产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
SERCA2 ATPase单克隆抗体(2A7-A1)
目录 :
MA3-919
规格 :
100微升
价格 :
美国449.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2A7-A1
反应物种 :
豚鼠, 人类, 小鼠, 大鼠, 犬, pigs , fruit fly , 家羊, domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 229
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:100; 图 1e
Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, et al. Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. EMBO Mol Med. 2021;13:e13074 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Feng D, Xu D, Murakoshi N, Tajiri K, Qin R, Yonebayashi S, et al. Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway. Int J Mol Sci. 2020;21: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 图 1g
Fajardo V, Chambers P, Juracic E, Rietze B, Gamu D, Bellissimo C, et al. Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology. Hum Mol Genet. 2018;27:4094-4102 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7a
Tanwar V, Gorr M, Velten M, Eichenseer C, Long V, Bonilla I, et al. In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood. J Am Heart Assoc. 2017;6: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s2f
Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2c
Fajardo V, Gamu D, Mitchell A, Bloemberg D, Bombardier E, Chambers P, et al. Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice. PLoS ONE. 2017;12:e0173708 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3e
Abad M, Hashimoto H, Zhou H, Morales M, Chen B, Bassel Duby R, et al. Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity. Stem Cell Reports. 2017;8:548-560 pubmed 出版商
  • 免疫印迹; 大鼠; 图 2e
Himori K, Abe M, Tatebayashi D, Lee J, Westerblad H, Lanner J, et al. Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension. PLoS ONE. 2017;12:e0169146 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2c
Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, et al. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017;595:1973-1986 pubmed 出版商
  • 免疫印迹; 小鼠; 图 10
Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 4a
  • 免疫印迹; 小鼠; 1:200; 图 4c
Martin L, Horst K, Chiazza F, Oggero S, Collino M, Brandenburg K, et al. The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci Rep. 2016;6:37277 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4c
Kennedy T, Swiderski K, Murphy K, Gehrig S, Curl C, Chandramouli C, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016;186:3246-3260 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed
  • 免疫印迹; 大鼠; 图 8
Hortemo K, Lunde P, Anonsen J, Kvaløy H, Munkvik M, Rehn T, et al. Exercise training increases protein O-GlcNAcylation in rat skeletal muscle. Physiol Rep. 2016;4: pubmed
  • 免疫印迹; 人类; 1:1000; 图 s2
Mannhardt I, Breckwoldt K, Letuffe Brenière D, Schaaf S, Schulz H, Neuber C, et al. Human Engineered Heart Tissue: Analysis of Contractile Force. Stem Cell Reports. 2016;7:29-42 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 1
Fajardo V, Smith I, Bombardier E, Chambers P, Quadrilatero J, Tupling A. Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers. Brain Behav. 2016;6:e00470 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2500; 图 s1
Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Nakagawa T, Yokoe S, Asahi M. Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase. Biochem Biophys Res Commun. 2016;472:523-30 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 s8a
Nelson B, Makarewich C, Anderson D, Winders B, Troupes C, Wu F, et al. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science. 2016;351:271-5 pubmed 出版商
  • 免疫印迹; 家羊; 图 1
Katz M, Brandon Warner E, Fargnoli A, Williams R, Kendle A, Hajjar R, et al. Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression. J Thorac Cardiovasc Surg. 2016;151:1191-200.e3 pubmed 出版商
  • 免疫印迹; 大鼠; 图 2
Zhang H, Cannell M, Kim S, Watson J, Norman R, Calaghan S, et al. Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload. PLoS ONE. 2015;10:e0144309 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Ge W, Yuan M, Ceylan A, Wang X, Ren J. Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. Biochim Biophys Acta. 2016;1862:622-634 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Fajardo V, Bombardier E, McMillan E, TRAN K, Wadsworth B, Gamu D, et al. Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype. Dis Model Mech. 2015;8:999-1009 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5
Dalpiaz P, Lamas A, Caliman I, Ribeiro R, Abreu G, Moyses M, et al. Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats. PLoS ONE. 2015;10:e0127515 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3.e,f
Yang L, Wang J, Yang J, Schamber R, Hu N, Nair S, et al. Antioxidant metallothionein alleviates endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction. Free Radic Res. 2015;49:1187-98 pubmed 出版商
  • 免疫印迹; 人类
Tang Y, Yin Y, Miao L, Wei B, Zhai K, Ji G. Nitric oxide enhances extracellular ATP induced Ca²⁺ oscillation in HeLa cells. Arch Biochem Biophys. 2015;565:68-75 pubmed 出版商
  • 免疫沉淀; domestic rabbit
  • 免疫印迹; domestic rabbit
Moshal K, Zhang Z, Roder K, Kim T, Cooper L, Patedakis Litvinov B, et al. Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes. Am J Physiol Cell Physiol. 2014;307:C1050-7 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Dweck D, Sanchez Gonzalez M, Chang A, Dulce R, Badger C, Koutnik A, et al. Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy. J Biol Chem. 2014;289:23097-111 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫组化; 小鼠
  • 免疫细胞化学; domestic rabbit
  • 免疫组化; domestic rabbit
  • 免疫印迹; 人类
Ljubojević S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, et al. Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure. Circulation. 2014;130:244-55 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6f
Katanosaka Y, Iwasaki K, Ujihara Y, Takatsu S, Nishitsuji K, Kanagawa M, et al. TRPV2 is critical for the maintenance of cardiac structure and function in mice. Nat Commun. 2014;5:3932 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Mourouzis I, Mantzouratou P, Galanopoulos G, Kostakou E, Dhalla A, Belardinelli L, et al. The beneficial effects of ranolazine on cardiac function after myocardial infarction are greater in diabetic than in nondiabetic rats. J Cardiovasc Pharmacol Ther. 2014;19:457-69 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000
Liu J, Sirenko S, Juhaszova M, Sollott S, Shukla S, Yaniv Y, et al. Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling. Am J Physiol Heart Circ Physiol. 2014;306:H1385-97 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Sivagangabalan G, Nazzari H, Bignolais O, Maguy A, Naud P, Farid T, et al. Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. PLoS ONE. 2014;9:e82179 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:1000; 图 4
  • 免疫沉淀; 人类; 图 6
  • 免疫印迹; 人类; 1:2000; 图 3
Fajardo V, Bombardier E, Vigna C, Devji T, Bloemberg D, Gamu D, et al. Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers. PLoS ONE. 2013;8:e84304 pubmed 出版商
  • 免疫印迹; 小鼠
Groenke S, Larson E, Alber S, Zhang R, Lamp S, Ren X, et al. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS ONE. 2013;8:e81633 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Kiyonaka S, Kajimoto T, Sakaguchi R, Shinmi D, Omatsu Kanbe M, Matsuura H, et al. Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nat Methods. 2013;10:1232-8 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Fares E, Pyle W, Ray G, Rose R, Denovan Wright E, Chen R, et al. The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart. PLoS ONE. 2013;8:e74719 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
Eshima H, Tanaka Y, Sonobe T, Inagaki T, Nakajima T, Poole D, et al. In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes. Am J Physiol Regul Integr Comp Physiol. 2013;305:R610-8 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Smith I, Bombardier E, Vigna C, Tupling A. ATP consumption by sarcoplasmic reticulum Ca²? pumps accounts for 40-50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle. PLoS ONE. 2013;8:e68924 pubmed 出版商
  • 免疫印迹; fruit fly
O Sullivan N, Dräger N, O Kane C. Characterization of the Drosophila atlastin interactome reveals VCP as a functionally related interactor. J Genet Genomics. 2013;40:297-306 pubmed 出版商
  • 免疫印迹; 小鼠
Chang A, Huang J, Battiprolu P, Hill J, Kamm K, Stull J. The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts. PLoS ONE. 2013;8:e66720 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Cheng Y, Wan X, McElfresh T, Chen X, Gresham K, Rosenbaum D, et al. Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere. Am J Physiol Heart Circ Physiol. 2013;305:H52-65 pubmed 出版商
  • 免疫组化; 大鼠; 1:500
Shortt C, Fredsted A, Bradford A, O Halloran K. Diaphragm muscle remodeling in a rat model of chronic intermittent hypoxia. J Histochem Cytochem. 2013;61:487-99 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Mourouzis I, Kostakou E, Galanopoulos G, Mantzouratou P, Pantos C. Inhibition of thyroid hormone receptor ?1 impairs post-ischemic cardiac performance after myocardial infarction in mice. Mol Cell Biochem. 2013;379:97-105 pubmed 出版商
  • 免疫印迹; 人类
Akimzhanov A, Barral J, Boehning D. Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release. Cell Calcium. 2013;53:152-8 pubmed 出版商
  • 免疫印迹; 人类
Middlekauff H, Vigna C, Verity M, Fonarow G, Horwich T, Hamilton M, et al. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?. J Card Fail. 2012;18:724-33 pubmed 出版商
  • 免疫组化; 大鼠
Guglielmino K, Jackson K, Harris T, Vu V, Dong H, Dutrow G, et al. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012;303:H853-62 pubmed 出版商
  • 免疫印迹; 大鼠
Sliwinska J, Dudka J, Korga A, Burdan F, Matysiak W, Jodlowska Jedrych B, et al. Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca²? balance protein levels. Oxid Med Cell Longev. 2012;2012:890826 pubmed 出版商
  • 免疫印迹; 犬
Moon M, Aziz A, Lee A, Moon C, Okada S, Kanter E, et al. Differential calcium handling in two canine models of right ventricular pressure overload. J Surg Res. 2012;178:554-62 pubmed 出版商
  • 免疫印迹; 大鼠
Korga A, Dudka J, Burdan F, Sliwinska J, Mandziuk S, Dawidek Pietryka K. The redox imbalance and the reduction of contractile protein content in rat hearts administered with L-thyroxine and Doxorubicin. Oxid Med Cell Longev. 2012;2012:681367 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Pinder J, Taylor Harris P, Bennett P, Carter E, Hayes N, King M, et al. Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system. Exp Cell Res. 2012;318:1467-79 pubmed 出版商
  • 免疫印迹; domestic rabbit
Odening K, Choi B, Liu G, Hartmann K, Ziv O, Chaves L, et al. Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective. Heart Rhythm. 2012;9:823-32 pubmed 出版商
  • 免疫印迹; 小鼠; 1:750
Da Silva D, Costa D, Alves C, Block B, Landeira Fernandez A. Temperature dependence of cardiac sarcoplasmic reticulum Ca²?-ATPase from rainbow trout Oncorhynchus mykiss. J Fish Biol. 2011;79:789-800 pubmed 出版商
  • 免疫印迹; 大鼠
Garcia Perez C, Schneider T, Hajnoczky G, Csordás G. Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points. Am J Physiol Heart Circ Physiol. 2011;301:H1907-15 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000
Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, Rios E. D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle. J Gen Physiol. 2011;138:211-29 pubmed 出版商
  • 免疫印迹; 人类
De Marchi U, Castelbou C, Demaurex N. Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production. J Biol Chem. 2011;286:32533-41 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000
Cheng Y, Li W, McElfresh T, Chen X, Berthiaume J, Castel L, et al. Changes in myofilament proteins, but not Ca²? regulation, are associated with a high-fat diet-induced improvement in contractile function in heart failure. Am J Physiol Heart Circ Physiol. 2011;301:H1438-46 pubmed 出版商
  • 免疫印迹; 小鼠; 1:4000
Thomas M, Vigna C, Betik A, Tupling A, Hepple R. Cardiac calcium pump inactivation and nitrosylation in senescent rat myocardium are not attenuated by long-term treadmill training. Exp Gerontol. 2011;46:803-10 pubmed 出版商
  • 免疫印迹; 人类
Lang D, Glukhov A, Efimova T, Efimov I. Role of Pyk2 in cardiac arrhythmogenesis. Am J Physiol Heart Circ Physiol. 2011;301:H975-83 pubmed 出版商
  • 免疫印迹; 小鼠
Staunton L, Jockusch H, Wiegand C, Albrecht T, Ohlendieck K. Identification of secondary effects of hyperexcitability by proteomic profiling of myotonic mouse muscle. Mol Biosyst. 2011;7:2480-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Coussee E, De Smet P, Bogaert E, Elens I, Van Damme P, Willems P, et al. G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production. Cell Calcium. 2011;49:217-25 pubmed 出版商
  • 免疫印迹; 家羊
Mariani J, Smolic A, Preovolos A, Byrne M, Power J, Kaye D. Augmentation of left ventricular mechanics by recirculation-mediated AAV2/1-SERCA2a gene delivery in experimental heart failure. Eur J Heart Fail. 2011;13:247-53 pubmed 出版商
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠; 1:1000
Kamkin A, Kiseleva I, Theres H, Eulert Grehn J, Wagner K, Scholz H, et al. Enhanced L-type calcium currents in cardiomyocytes from transgenic rats overexpressing SERCA2a. Exp Clin Cardiol. 2010;15:e109-15 pubmed
  • 免疫印迹; 小鼠; 1:1000
Horiuchi Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, et al. Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes. Am J Physiol Heart Circ Physiol. 2011;300:H978-88 pubmed 出版商
  • 免疫印迹; 小鼠
Hougen K, Aronsen J, Stokke M, Enger U, Nygard S, Andersson K, et al. Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice. Am J Physiol Heart Circ Physiol. 2010;299:H1671-8 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Kalofoutis C, Mourouzis I, Galanopoulos G, Dimopoulos A, Perimenis P, Spanou D, et al. Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction. Mol Cell Biochem. 2010;345:161-9 pubmed 出版商
  • 免疫印迹; 小鼠
Chandrasekharan K, Yoon J, Xu Y, DeVries S, Camboni M, Janssen P, et al. A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Sci Transl Med. 2010;2:42ra54 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Jasuja R, Furie B, Furie B. Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo. Blood. 2010;116:4665-74 pubmed 出版商
  • 免疫沉淀; 大鼠
  • 免疫印迹; 大鼠; 1:3000
  • 免疫印迹; 人类; 1:3000
Yokoe S, Asahi M, Takeda T, Otsu K, Taniguchi N, Miyoshi E, et al. Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy. Glycobiology. 2010;20:1217-26 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Jeong M, Walker J, Brown R, Moore R, Vinson C, Colucci W, et al. AFos inhibits phenylephrine-mediated contractile dysfunction by altering phospholamban phosphorylation. Am J Physiol Heart Circ Physiol. 2010;298:H1719-26 pubmed 出版商
  • 免疫印迹; 大鼠; 1:4000
Thomas M, Vigna C, Betik A, Tupling A, Hepple R. Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1269-78 pubmed 出版商
  • 免疫组化; 犬; 1:1000
Summerfield N, Peters M, Hercock C, Mobasheri A, Young I. Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium. J Vet Cardiol. 2010;12:17-23 pubmed 出版商
  • 免疫印迹; 小鼠
Louch W, Hougen K, Mørk H, Swift F, Aronsen J, Sjaastad I, et al. Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout. J Physiol. 2010;588:465-78 pubmed 出版商
  • 免疫印迹; 人类
Munkvik M, Rehn T, Slettaløkken G, Hasic A, Hallen J, Sjaastad I, et al. Training effects on skeletal muscle calcium handling in human chronic heart failure. Med Sci Sports Exerc. 2010;42:847-55 pubmed 出版商
  • 免疫印迹; 小鼠
Andersson K, Finsen A, Sjåland C, Winer L, Sjaastad I, Odegaard A, et al. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 2009;46:219-25 pubmed 出版商
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Chaudhri B, Del Monte F, Hajjar R, Harding S. Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes. Am J Physiol Heart Circ Physiol. 2002;283:H2450-7 pubmed
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图像
图像 1 :
赛默飞世尔 MA3-919 图像 1
Immunofluorescent analysis of SERCA2 ATPase using SERCA2 ATPase Monoclonal antibody (2A7-A1) (Product# MA3-919) shows staining in U251 glioma cells. SERCA2 ATPase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing SERCA2 ATPase (Product# MA3-919) at a dilution of 1:100-1:200 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
产品信息
产品类型 :
抗体
产品名称 :
SERCA2 ATPase单克隆抗体(2A7-A1)
目录# :
MA3-919
规格 :
100微升
价格 :
美国449.00
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
狗, 豚鼠, 人类, 小鼠, 猪, 兔, 大鼠
应用 :
Flow Cytometry: 1:20, Immunocytochemistry: 1:100-1:250, Immunohistochemistry (Frozen): 1/100, Immunohistochemistry (Paraffin): 1 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
物种 :
狗, 豚鼠, 人类, 小鼠, 猪, 兔, 大鼠
克隆 :
2A7-A1
抗体亚型 :
IgG2a
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
免疫原 :
Purified canine cardiac sarcoplasmic reticulum vesicles.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1:20, Immunocytochemistry: 1:100-1:250, Immunohistochemistry (Frozen): 1/100, Immunohistochemistry (Paraffin): 1 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
别名 :
9530097L16Rik; ATP2; Atp2a2; ATP2B; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; Ca(2+)-transport ATPase class 3; calcium ATPase; calcium pump 2; calcium-ATPase (EC 3.6.1.3); calcium-transporting ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; D5Wsu150e; DAR; DD; endoplasmic reticulum class 1/2 Ca(2+) ATPase; mKIAA4195; putative SERCA isoform; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; sarcoplasmic reticulum Ca2+-transport ATPase isoform; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2; SERCA; SERCA ATPase; SERCA2; Serca2a; SERCA2B; SercaII; SR Ca(2+)-ATPase 2; unnamed protein product
更多信息或购买 :
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公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国