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抗体

糖皮质激素受体单克隆抗体(5E4), 异硫氰酸荧光素

MA1-81793

100微克

美国804.00

单克隆

小鼠

异硫氰酸荧光素

5E4

人类, 小鼠

免疫细胞化学, 流式细胞仪

糖皮质激素受体单克隆抗体(5E4), 异硫氰酸荧光素

MA1-81793

100微克

美国804.00

单克隆

离子交换层析

小鼠

人类

Flow Cytometry: Neat-1:10, Immunocytochemistry: 5 µg/mL

人类

5E4

IgG1

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity

26 amino acid peptide corresponding to residues 150-176 on human GCR linked thyroglobulin.

液体

Flow Cytometry: Neat-1:10, Immunocytochemistry: 5 µg/mL

cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038