产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
糖皮质激素受体单克隆抗体(BuGR2)
目录 :
MA1-510
规格 :
100微克
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
BuGR2
反应物种 :
豚鼠, African green monkey, fission yeast, 人类, 小鼠, 大鼠, 家羊, domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化基因敲除验证
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 172
出版应用/物种/样本/稀释参考文献
  • 免疫组化基因敲除验证; 小鼠; 1:500; 图 s1d
  • 免疫组化; 小鼠; 1:500; 图 s1e
Marchetta P, Eckert P, Lukowski R, Ruth P, Singer W, R xfc ttiger L, et al. Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea. iScience. 2022;25:103981 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 图 4a
Yasuda M, Shinoda M, Honda K, Fujita M, Kawata A, Nagashima H, et al. Maternal Separation Induces Orofacial Mechanical Allodynia in Adulthood. J Dent Res. 2016;95:1191-7 pubmed 出版商
  • 免疫印迹; 小鼠; 1:6000; 图 3
Demuyser T, Bentea E, Deneyer L, Albertini G, Massie A, Smolders I. Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice. Neurosci Lett. 2016;626:119-25 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 图 1d
  • 免疫印迹; 小鼠; 图 s3c
Ma X, Xu L, Mueller E. Forkhead box A3 mediates glucocorticoid receptor function in adipose tissue. Proc Natl Acad Sci U S A. 2016;113:3377-82 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Baker G, Murphy T, Block T, Nguyen D, Lynch F. Development and validation of an immunohistochemistry assay to assess glucocorticoid receptor expression for clinical trials of mifepristone in breast cancer. Cancer Manag Res. 2015;7:361-8 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠; 图 2
Arango Lievano M, Lambert W, Bath K, Garabedian M, Chao M, Jeanneteau F. Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment. Proc Natl Acad Sci U S A. 2015;112:15737-42 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Stavreva D, Coulon A, Baek S, Sung M, John S, Stixova L, et al. Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing. Genome Res. 2015;25:845-57 pubmed 出版商
  • 免疫组化; 家羊; 1:50
  • 免疫印迹; 家羊; 1:1000
Shang H, Meng W, Sloboda D, Li S, Ehrlich L, Plagemann A, et al. Effects of maternal dexamethasone treatment early in pregnancy on glucocorticoid receptors in the ovine placenta. Reprod Sci. 2015;22:534-44 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Connors E, Shaik A, Migliore M, Kentner A. Environmental enrichment mitigates the sex-specific effects of gestational inflammation on social engagement and the hypothalamic pituitary adrenal axis-feedback system. Brain Behav Immun. 2014;42:178-90 pubmed 出版商
  • 免疫印迹; 大鼠
Zhu R, Lu X, Pradhan M, Armstrong S, Storchan G, Chow C, et al. A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction. Biochemistry. 2014;53:1753-67 pubmed 出版商
  • 免疫组化; 小鼠
Sultana R, Theodoraki M, Caplan A. Specificity in the actions of the UBR1 ubiquitin ligase in the degradation of nuclear receptors. FEBS Open Bio. 2013;3:394-7 pubmed 出版商
  • 免疫沉淀; African green monkey
Luo M, Lu X, Zhu R, Zhang Z, Chow C, Li R, et al. A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties. J Biol Chem. 2013;288:34055-72 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠; 3 ug/time
Evans A, Liu Y, MACGREGOR R, Huang V, Aguilera G. Regulation of hypothalamic corticotropin-releasing hormone transcription by elevated glucocorticoids. Mol Endocrinol. 2013;27:1796-807 pubmed 出版商
  • 免疫印迹; 大鼠
Adzic M, Lukic I, Mitic M, Djordjevic J, Elaković I, Djordjevic A, et al. Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: effects on energy metabolism. Psychoneuroendocrinology. 2013;38:2914-24 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠
  • 染色质免疫沉淀 ; 人类
Lambert W, Xu C, Neubert T, Chao M, Garabedian M, Jeanneteau F. Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol Cell Biol. 2013;33:3700-14 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Zhang L, Prak L, Rayon Estrada V, Thiru P, Flygare J, Lim B, et al. ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Nature. 2013;499:92-6 pubmed 出版商
  • 免疫组化; 大鼠; 1:1000
Wisłowska Stanek A, Lehner M, Skorzewska A, Maciejak P, Szyndler J, Turzynska D, et al. Corticosterone modulates fear responses and the expression of glucocorticoid receptors in the brain of high-anxiety rats. Neurosci Lett. 2013;533:17-22 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠; 2 ug/time
Zhang Z, Sun Y, Cho Y, Chow C, Simons S. PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. J Biol Chem. 2013;288:42-58 pubmed 出版商
  • 免疫印迹; 人类; 图 1d
  • 免疫印迹; 大鼠
Blackford J, Guo C, Zhu R, Dougherty E, Chow C, Simons S. Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation. J Biol Chem. 2012;287:40982-95 pubmed 出版商
  • 免疫印迹; 大鼠; 1:6000
Cory Slechta D, Virgolini M, Liu S, Weston D. Enhanced stimulus sequence-dependent repeated learning in male offspring after prenatal stress alone or in conjunction with lead exposure. Neurotoxicology. 2012;33:1188-202 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Awasthi S, Simons S. Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction. Mol Cell Endocrinol. 2012;355:121-34 pubmed 出版商
  • 免疫沉淀; 小鼠
Pang X, Cheng J, Kim J, Matsubara T, Krausz K, Gonzalez F. Expression and regulation of human fetal-specific CYP3A7 in mice. Endocrinology. 2012;153:1453-63 pubmed 出版商
  • 免疫沉淀; 大鼠
Jeanneteau F, Lambert W, Ismaili N, Bath K, Lee F, Garabedian M, et al. BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A. 2012;109:1305-10 pubmed 出版商
  • 免疫沉淀; 小鼠
Voss T, Schiltz R, Sung M, Yen P, Stamatoyannopoulos J, Biddie S, et al. Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. Cell. 2011;146:544-54 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫沉淀; 大鼠
  • 免疫印迹; 大鼠; 0.2 ug/ml
Gallo L, Lagadari M, Piwien Pilipuk G, Galigniana M. The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress. J Biol Chem. 2011;286:30152-60 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Wiench M, John S, Baek S, Johnson T, Sung M, Escobar T, et al. DNA methylation status predicts cell type-specific enhancer activity. EMBO J. 2011;30:3028-39 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Siersbæk R, Nielsen R, John S, Sung M, Baek S, Loft A, et al. Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J. 2011;30:1459-72 pubmed 出版商
  • 流式细胞仪; 人类
Gao L, Wang J, Xiang M, Fan Y, Zhang Z, Wang K. Expression of human glucocorticoid receptor in T lymphocytes in acute-on-chronic hepatitis B liver failure. Dig Dis Sci. 2011;56:2605-12 pubmed 出版商
  • 免疫沉淀; 人类
John S, Sabo P, Thurman R, Sung M, Biddie S, Johnson T, et al. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet. 2011;43:264-8 pubmed 出版商
  • 免疫组化; 大鼠; 1:100
  • 免疫印迹; 大鼠; 1:200
Prager E, Brielmaier J, Bergstrom H, McGuire J, Johnson L. Localization of mineralocorticoid receptors at mammalian synapses. PLoS ONE. 2010;5:e14344 pubmed 出版商
  • 免疫印迹; 小鼠
Bertucci P, Quaglino A, Pozzi A, Kordon E, Pecci A. Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation. Endocrinology. 2010;151:5730-40 pubmed 出版商
  • 免疫印迹; 人类
Rossi George A, Virgolini M, Weston D, Thiruchelvam M, Cory Slechta D. Interactions of lifetime lead exposure and stress: behavioral, neurochemical and HPA axis effects. Neurotoxicology. 2011;32:83-99 pubmed 出版商
  • 免疫印迹; 小鼠
Quintá H, Maschi D, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J Neurochem. 2010;115:716-34 pubmed 出版商
  • 免疫印迹; 小鼠; 0.25 ug/ml
Wang A, Morishima Y, Clapp K, Peng H, Pratt W, Gestwicki J, et al. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem. 2010;285:15714-23 pubmed 出版商
  • 免疫沉淀; 人类
Mandal A, Gibney P, Nillegoda N, Theodoraki M, Caplan A, Morano K. Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. Mol Biol Cell. 2010;21:1439-48 pubmed 出版商
  • 免疫沉淀; 大鼠
Arambasić J, Poznanovic G, Ivanovic Matic S, Bogojevic D, Mihailovic M, Uskoković A, et al. Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. IUBMB Life. 2010;62:227-36 pubmed 出版商
  • 免疫沉淀; 大鼠
  • 免疫印迹; 大鼠
Elaković I, Vasiljević D, Adzic M, Djordjevic A, Djordjevic J, Radojcic M, et al. Sexually dimorphic functional alterations of rat hepatic glucocorticoid receptor in response to fluoxetine. Eur J Pharmacol. 2010;632:79-85 pubmed 出版商
  • 免疫印迹; 小鼠
Galigniana M, Erlejman A, Monte M, Gomez Sanchez C, Piwien Pilipuk G. The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events. Mol Cell Biol. 2010;30:1285-98 pubmed 出版商
  • 免疫印迹; 大鼠
Adzic M, Djordjevic A, Demonacos C, Krstic Demonacos M, Radojcic M. The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats. Int J Biochem Cell Biol. 2009;41:2181-8 pubmed 出版商
  • 免疫组化; fission yeast; 5 ug/ml
Simmons R, Satterfield M, Welsh T, Bazer F, Spencer T. HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau. Biol Reprod. 2010;82:35-43 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
Echeverria P, Mazaira G, Erlejman A, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol. 2009;29:4788-97 pubmed 出版商
  • 免疫印迹; 大鼠
Kawabata K, Kawai Y, Terao J. Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats. J Nutr Biochem. 2010;21:374-80 pubmed 出版商
  • 免疫组化; 小鼠
Dong H, Yuede C, Yoo H, Martin M, Deal C, Mace A, et al. Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice. Neuroscience. 2008;155:154-63 pubmed 出版商
  • 免疫细胞化学; African green monkey; 1:350
Haffner M, Jurgeit A, Berlato C, Geley S, Parajuli N, Yoshimura A, et al. Interaction and functional interference of glucocorticoid receptor and SOCS1. J Biol Chem. 2008;283:22089-96 pubmed 出版商
  • EMSA; 大鼠
  • 免疫沉淀; 大鼠
  • 免疫印迹; 大鼠; 1:5000
Vujcić M, Velickovic N, Ruzdijic S. Dexamethasone treatment affects nuclear glucocorticoid receptor and glucocorticoid response element binding activity in liver of rats (Rattus norvegicus) during aging. Comp Biochem Physiol B Biochem Mol Biol. 2007;148:463-9 pubmed
  • 免疫印迹; 大鼠
Wang D, Wang Q, Awasthi S, Simons S. Amino-terminal domain of TIF2 is involved in competing for corepressor binding to glucocorticoid and progesterone receptors. Biochemistry. 2007;46:8036-49 pubmed
  • 免疫组化; 家羊; 1:60
Antonow Schlorke I, Muller T, Brodhun M, Wicher C, Schubert H, Nathanielsz P, et al. Betamethasone-related acute alterations of microtubule-associated proteins in the fetal sheep brain are reversible and independent of age during the last one-third of gestation. Am J Obstet Gynecol. 2007;196:553.e1-6 pubmed
  • 免疫印迹; 大鼠; 1:250
Morsink M, Joels M, Sarabdjitsingh R, Meijer O, de Kloet E, Datson N. The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells. J Neurochem. 2006;99:1282-98 pubmed
  • 免疫沉淀; 小鼠
  • 免疫细胞化学; 小鼠; 1:50
  • 免疫印迹; 小鼠; 1:500
Presman D, Hoijman E, Ceballos N, Galigniana M, Pecci A. Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes. Endocrinology. 2006;147:5452-9 pubmed
  • 流式细胞仪; 小鼠
Erlacher M, Knoflach M, Stec I, Böck G, Wick G, Wiegers G. TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development. Eur J Immunol. 2005;35:3287-96 pubmed
  • 免疫印迹; 大鼠; 1:6000
Virgolini M, Chen K, Weston D, Bauter M, Cory Slechta D. Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function. Toxicol Sci. 2005;87:469-82 pubmed
  • 免疫组化; 小鼠
Webster J, Sternberg E. Anthrax lethal toxin represses glucocorticoid receptor (GR) transactivation by inhibiting GR-DNA binding in vivo. Mol Cell Endocrinol. 2005;241:21-31 pubmed
Yao D, Lu Y, Li L, Wang S, Mu Y, Ding C, et al. Prolactin and glucocorticoid receptors in the prefrontal cortex are associated with anxiety-like behavior in prenatally stressed adolescent offspring rats. J Neuroendocrinol. 2023;35:e13231 pubmed 出版商
Præstholm S, Correia C, Goitea V, Siersbæk M, Jørgensen M, Havelund J, et al. Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage. Cell Rep. 2021;37:109938 pubmed 出版商
Yu P, Liu M, Zhang B, Yu Y, Su E, Xie S, et al. Cardiomyocyte-restricted high-mobility group box 1 (HMGB1) deletion leads to small heart and glycolipid metabolic disorder through GR/PGC-1α signalling. Cell Death Discov. 2020;6:106 pubmed 出版商
Adrienne McGinn M, Edwards K, Edwards S. Chronic inflammatory pain alters alcohol-regulated frontocortical signaling and associations between alcohol drinking and thermal sensitivity. Neurobiol Pain. 2020;8:100052 pubmed 出版商
Mazaira G, Echeverria P, Galigniana M. Nucleocytoplasmic shuttling of the glucocorticoid receptor is influenced by tetratricopeptide repeat-containing proteins. J Cell Sci. 2020;133: pubmed 出版商
Palumbo M, Dominguez S, Dong H. Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress. Brain Behav. 2020;10:e01586 pubmed 出版商
Ogara M, Rodríguez Seguí S, Marini M, Nacht A, Stortz M, Levi V, et al. The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells. Nucleic Acids Res. 2019;47:10645-10661 pubmed 出版商
Stavreva D, Garcia D, Fettweis G, Gudla P, Zaki G, Soni V, et al. Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility. Mol Cell. 2019;75:1161-1177.e11 pubmed 出版商
Kalvisa A, Siersbæk M, Præstholm S, Christensen L, Nielsen R, Stöhr O, et al. Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver. PLoS Biol. 2018;16:e2006249 pubmed 出版商
Sobolewski M, Varma G, Adams B, Anderson D, Schneider J, Cory Slechta D. Developmental Lead Exposure and Prenatal Stress Result in Sex-Specific Reprograming of Adult Stress Physiology and Epigenetic Profiles in Brain. Toxicol Sci. 2018;163:478-489 pubmed 出版商
Jubb A, Boyle S, Hume D, Bickmore W. Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. Cell Rep. 2017;21:3022-3031 pubmed 出版商
Oh K, Patel H, Gottschalk R, Lee W, Baek S, Fraser I, et al. Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action. Immunity. 2017;47:298-309.e5 pubmed 出版商
Gauthier M, Chakraborty K, Oriss T, Raundhal M, Das S, Chen J, et al. Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias. JCI Insight. 2017;2: pubmed 出版商
Flom G, Lemieszek M, Fortunato E, Johnson J. Farnesylation of Ydj1 is required for in vivo interaction with Hsp90 client proteins. Mol Biol Cell. 2008;19:5249-58 pubmed 出版商
Hawle P, Siepmann M, Harst A, Siderius M, Reusch H, Obermann W. The middle domain of Hsp90 acts as a discriminator between different types of client proteins. Mol Cell Biol. 2006;26:8385-95 pubmed
Heitzer M, DeFranco D. Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator. Mol Endocrinol. 2006;20:56-64 pubmed
Barish G, Downes M, Alaynick W, Yu R, Ocampo C, Bookout A, et al. A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol. 2005;19:2466-77 pubmed
Carrigan P, Riggs D, Chinkers M, Smith D. Functional comparison of human and Drosophila Hop reveals novel role in steroid receptor maturation. J Biol Chem. 2005;280:8906-11 pubmed
Brkljacic J, Milutinović D, Dundjerski J, Matić G. Mercury stimulates rat liver glucocorticoid receptor association with Hsp90 and Hsp70. J Biochem Mol Toxicol. 2004;18:257-60 pubmed
Cho S, Kagan B, Blackford J, Szapary D, Simons S. Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9. Mol Endocrinol. 2005;19:290-311 pubmed
Harrell J, Murphy P, Morishima Y, Chen H, Mansfield J, Galigniana M, et al. Evidence for glucocorticoid receptor transport on microtubules by dynein. J Biol Chem. 2004;279:54647-54 pubmed
Wei Q, Lu X, Liu L, Schafer G, Shieh K, Burke S, et al. Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Natl Acad Sci U S A. 2004;101:11851-6 pubmed
Billecke S, Draganov D, Morishima Y, Murphy P, Dunbar A, Pratt W, et al. The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase. J Biol Chem. 2004;279:30252-8 pubmed
Hoetzenecker W, Meingassner J, Ecker R, Stingl G, Stuetz A, Elbe Bürger A. Corticosteroids but not pimecrolimus affect viability, maturation and immune function of murine epidermal Langerhans cells. J Invest Dermatol. 2004;122:673-84 pubmed
Nelson G, Prapapanich V, Carrigan P, Roberts P, Riggs D, Smith D. The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor. Mol Endocrinol. 2004;18:1620-30 pubmed
Wang Q, Blackford J, Song L, Huang Y, Cho S, Simons S. Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors. Mol Endocrinol. 2004;18:1376-95 pubmed
Kutzler M, Ruane E, Coksaygan T, Vincent S, Nathanielsz P. Effects of three courses of maternally administered dexamethasone at 0.7, 0.75, and 0.8 of gestation on prenatal and postnatal growth in sheep. Pediatrics. 2004;113:313-9 pubmed
Viegas L, Vicent G, Barañao J, Beato M, Pecci A. Steroid hormones induce bcl-X gene expression through direct activation of distal promoter P4. J Biol Chem. 2004;279:9831-9 pubmed
Morishima Y, Kanelakis K, Murphy P, Lowe E, Jenkins G, Osawa Y, et al. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J Biol Chem. 2003;278:48754-63 pubmed
Hoijman E, Rocha Viegas L, Keller Sarmiento M, Rosenstein R, Pecci A. Involvement of Bax protein in the prevention of glucocorticoid-induced thymocytes apoptosis by melatonin. Endocrinology. 2004;145:418-25 pubmed
Kasai M, Guerrero Santoro J, Friedman R, Leman E, Getzenberg R, DeFranco D. The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines. Cancer Res. 2003;63:4927-35 pubmed
Tjandra K, Le T, Swain M. Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitis. Gut. 2003;52:1363-70 pubmed
Walther R, Lamprecht C, Ridsdale A, Groulx I, Lee S, Lefebvre Y, et al. Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin. J Biol Chem. 2003;278:37858-64 pubmed
Murphy P, Morishima Y, Chen H, Galigniana M, Mansfield J, Simons S, et al. Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. J Biol Chem. 2003;278:34764-73 pubmed
Lambert J, Nordeen S. CBP recruitment and histone acetylation in differential gene induction by glucocorticoids and progestins. Mol Endocrinol. 2003;17:1085-94 pubmed
Patel A, Bulloch K. Type II glucocorticoid receptor immunoreactivity in the mossy cells of the rat and the mouse hippocampus. Hippocampus. 2003;13:59-66 pubmed
Riggs D, Roberts P, Chirillo S, Cheung Flynn J, Prapapanich V, Ratajczak T, et al. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J. 2003;22:1158-67 pubmed
Li Q, Su A, Chen J, Lefebvre Y, Haché R. Attenuation of glucocorticoid signaling through targeted degradation of p300 via the 26S proteasome pathway. Mol Endocrinol. 2002;16:2819-27 pubmed
Brewer J, Kanagawa O, Sleckman B, Muglia L. Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol. 2002;169:1837-43 pubmed
Kanelakis K, Shewach D, Pratt W. Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly. J Biol Chem. 2002;277:33698-703 pubmed
Harrell J, Kurek I, Breiman A, Radanyi C, Renoir J, Pratt W, et al. All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells. Biochemistry. 2002;41:5581-7 pubmed
Piwien Pilipuk G, Kanelakis K, Ghini A, Lantos C, Litwack G, Burton G, et al. Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxidoprogesterone. Biochim Biophys Acta. 2002;1589:31-48 pubmed
Murphy E, Spencer R, Sipe K, Herman J. Decrements in nuclear glucocorticoid receptor (GR) protein levels and DNA binding in aged rat hippocampus. Endocrinology. 2002;143:1362-70 pubmed
Davies T, Ning Y, SANCHEZ E. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 2002;277:4597-600 pubmed
Proulx K, Clavel S, Nault G, Richard D, Walker C. High neonatal leptin exposure enhances brain GR expression and feedback efficacy on the adrenocortical axis of developing rats. Endocrinology. 2001;142:4607-16 pubmed
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Soubeyrand S, Torrance H, Giffin W, Gong W, Schild Poulter C, Hache R. Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins. Proc Natl Acad Sci U S A. 2001;98:9605-10 pubmed
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Murphy P, Kanelakis K, Galigniana M, Morishima Y, Pratt W. Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate. J Biol Chem. 2001;276:30092-8 pubmed
Belikov S, Gelius B, Wrange O. Hormone-induced nucleosome positioning in the MMTV promoter is reversible. EMBO J. 2001;20:2802-11 pubmed
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Wyszomierski S, Rosen J. Cooperative effects of STAT5 (signal transducer and activator of transcription 5) and C/EBPbeta (CCAAT/enhancer-binding protein-beta) on beta-casein gene transcription are mediated by the glucocorticoid receptor. Mol Endocrinol. 2001;15:228-40 pubmed
Savory J, Préfontaine G, Lamprecht C, Liao M, Walther R, Lefebvre Y, et al. Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces. Mol Cell Biol. 2001;21:781-93 pubmed
Kanelakis K, Murphy P, Galigniana M, Morishima Y, Takayama S, Reed J, et al. hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1. Biochemistry. 2000;39:14314-21 pubmed
Rajapandi T, Greene L, Eisenberg E. The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor. J Biol Chem. 2000;275:22597-604 pubmed
Johnson J, Craig E. A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast. Mol Cell Biol. 2000;20:3027-36 pubmed
Morishima Y, Kanelakis K, Silverstein A, Dittmar K, Estrada L, Pratt W. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. J Biol Chem. 2000;275:6894-900 pubmed
Giannoukos G, Silverstein A, Pratt W, Simons S. The seven amino acids (547-553) of rat glucocorticoid receptor required for steroid and hsp90 binding contain a functionally independent LXXLL motif that is critical for steroid binding. J Biol Chem. 1999;274:36527-36 pubmed
Kanelakis K, Morishima Y, Dittmar K, Galigniana M, Takayama S, Reed J, et al. Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery. J Biol Chem. 1999;274:34134-40 pubmed
Sacedon R, Vicente A, Varas A, Jimenez E, Munoz J, Zapata A. Early maturation of T-cell progenitors in the absence of glucocorticoids. Blood. 1999;94:2819-26 pubmed
Herman J, Watson S, Spencer R. Defense of adrenocorticosteroid receptor expression in rat hippocampus: effects of stress and strain. Endocrinology. 1999;140:3981-91 pubmed
Sacedon R, Vicente A, Varas A, Jimenez E, Munoz J, Zapata A. Glucocorticoid-mediated regulation of thymic dendritic cell function. Int Immunol. 1999;11:1217-24 pubmed
Towns R, Menon K, Brabec R, Silverstein A, Cohen J, Bowen J, et al. Glucocorticoids stimulate the accumulation of lipids in the rat corpus luteum. Biol Reprod. 1999;61:416-21 pubmed
Galigniana M, Housley P, DeFranco D, Pratt W. Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton. J Biol Chem. 1999;274:16222-7 pubmed
Nogami H, Inoue K, Moriya H, Ishida A, Kobayashi S, Hisano S, et al. Regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression by glucocorticoids in MtT-S cells and in the pituitary gland of fetal rats. Endocrinology. 1999;140:2763-70 pubmed
Reynolds P, Ruan Y, Smith D, Scammell J. Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51. J Clin Endocrinol Metab. 1999;84:663-9 pubmed
Wyszomierski S, Yeh J, Rosen J. Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. Mol Endocrinol. 1999;13:330-43 pubmed
Jun S, Chen Z, Pace M, Shaul P. Glucocorticoids downregulate cyclooxygenase-1 gene expression and prostacyclin synthesis in fetal pulmonary artery endothelium. Circ Res. 1999;84:193-200 pubmed
Savory J, Hsu B, Laquian I, Giffin W, Reich T, Hache R, et al. Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor. Mol Cell Biol. 1999;19:1025-37 pubmed
Chandran U, Warren B, Baumann C, Hager G, DeFranco D. The glucocorticoid receptor is tethered to DNA-bound Oct-1 at the mouse gonadotropin-releasing hormone distal negative glucocorticoid response element. J Biol Chem. 1999;274:2372-8 pubmed
Bender A, Silverstein A, Demady D, Kanelakis K, Noguchi S, Pratt W, et al. Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo. J Biol Chem. 1999;274:1472-8 pubmed
Hache R, Tse R, Reich T, Savory J, Lefebvre Y. Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor. J Biol Chem. 1999;274:1432-9 pubmed
Herman J, Spencer R. Regulation of hippocampal glucocorticoid receptor gene transcription and protein expression in vivo. J Neurosci. 1998;18:7462-73 pubmed
Tang Y, Getzenberg R, Vietmeier B, Stallcup M, Eggert M, Renkawitz R, et al. The DNA-binding and tau2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix-targeting signal. Mol Endocrinol. 1998;12:1420-31 pubmed
Caamaño C, Morano M, Dalman F, Pratt W, Akil H. A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling. J Biol Chem. 1998;273:20473-80 pubmed
Dittmar K, Banach M, Galigniana M, Pratt W. The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex. J Biol Chem. 1998;273:7358-66 pubmed
Barent R, Nair S, Carr D, Ruan Y, Rimerman R, Fulton J, et al. Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes. Mol Endocrinol. 1998;12:342-54 pubmed
Dittmar K, Demady D, Stancato L, Krishna P, Pratt W. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. J Biol Chem. 1997;272:21213-20 pubmed
Silverstein A, Galigniana M, Chen M, Owens Grillo J, Chinkers M, Pratt W. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. J Biol Chem. 1997;272:16224-30 pubmed
Dittmar K, Pratt W. Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. J Biol Chem. 1997;272:13047-54 pubmed
Sackey F, Hache R, Reich T, Kwast Welfeld J, Lefebvre Y. Determinants of subcellular distribution of the glucocorticoid receptor. Mol Endocrinol. 1996;10:1191-205 pubmed
Hong H, Kohli K, Garabedian M, Stallcup M. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol Cell Biol. 1997;17:2735-44 pubmed
Chang H, Nathan D, Lindquist S. In vivo analysis of the Hsp90 cochaperone Sti1 (p60). Mol Cell Biol. 1997;17:318-25 pubmed
Chen M, Silverstein A, Pratt W, Chinkers M. The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. J Biol Chem. 1996;271:32315-20 pubmed
Dittmar K, Hutchison K, Owens Grillo J, Pratt W. Reconstitution of the steroid receptor.hsp90 heterocomplex assembly system of rabbit reticulocyte lysate. J Biol Chem. 1996;271:12833-9 pubmed
Curtis L, Rarey K. Effect of stress on cochlear glucocorticoid protein. II. Restraint. Hear Res. 1995;92:120-5 pubmed
Huss J, Wang S, Astrom A, McQuiddy P, Kasper C. Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc Natl Acad Sci U S A. 1996;93:4666-70 pubmed
Stancato L, Silverstein A, Gitler C, Groner B, Pratt W. Use of the thiol-specific derivatizing agent N-iodoacetyl-3-[125I]iodotyrosine to demonstrate conformational differences between the unbound and hsp90-bound glucocorticoid receptor hormone binding domain. J Biol Chem. 1996;271:8831-6 pubmed
Chang T, Scher B, Waxman S, Scher W. Inhibition of mouse GATA-1 function by the glucocorticoid receptor: possible mechanism of steroid inhibition of erythroleukemia cell differentiation. Mol Endocrinol. 1993;7:528-42 pubmed
Stancato L, Chow Y, Hutchison K, Perdew G, Jove R, Pratt W. Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. J Biol Chem. 1993;268:21711-6 pubmed
Opoku J, Simons S. Absence of intramolecular disulfides in the structure and function of native rat glucocorticoid receptors. J Biol Chem. 1994;269:503-10 pubmed
Czar M, Owens Grillo J, Dittmar K, Hutchison K, Zacharek A, Leach K, et al. Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex. J Biol Chem. 1994;269:11155-61 pubmed
Hutchison K, Dittmar K, Czar M, Pratt W. Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90. J Biol Chem. 1994;269:5043-9 pubmed
Smets L, van Den Berg J, Acton D, Top B, Van Rooij H, Verwijs Janssen M. BCL-2 expression and mitochondrial activity in leukemic cells with different sensitivity to glucocorticoid-induced apoptosis. Blood. 1994;84:1613-9 pubmed
Kupfer S, Wilson E, French F. Androgen and glucocorticoid receptors interact with insulin degrading enzyme. J Biol Chem. 1994;269:20622-8 pubmed
Garlatti M, Daheshia M, Slater E, Bouguet J, Hanoune J, Beato M, et al. A functional glucocorticoid-responsive unit composed of two overlapping inactive receptor-binding sites: evidence for formation of a receptor tetramer. Mol Cell Biol. 1994;14:8007-17 pubmed
Hutchison K, Dittmar K, Pratt W. All of the factors required for assembly of the glucocorticoid receptor into a functional heterocomplex with heat shock protein 90 are preassociated in a self-sufficient protein folding structure, a "foldosome". J Biol Chem. 1994;269:27894-9 pubmed
van den Berg J, Smets L, Hutchison K, Van Rooij H, van den Elshout M. High levels of non-activated receptors in glucocorticoid-sensitive S49wt mouse lymphoma cells incubated with dexamethasone. J Steroid Biochem Mol Biol. 1994;51:33-40 pubmed
Modarress K, Cavanaugh A, Chakraborti P, Simons S. Metal oxyanion stabilization of the rat glucocorticoid receptor is independent of thiols. J Biol Chem. 1994;269:25621-8 pubmed
Chang H, Lindquist S. Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae. J Biol Chem. 1994;269:24983-8 pubmed
Rarey K, Gerhardt K, Curtis L, ten Cate W. Effect of stress on cochlear glucocorticoid protein: acoustic stress. Hear Res. 1995;82:135-8 pubmed
Owens Grillo J, Hoffmann K, Hutchison K, Yem A, Deibel M, Handschumacher R, et al. The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor. J Biol Chem. 1995;270:20479-84 pubmed
Hutchison K, Stancato L, Owens Grillo J, Johnson J, Krishna P, Toft D, et al. The 23-kDa acidic protein in reticulocyte lysate is the weakly bound component of the hsp foldosome that is required for assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90. J Biol Chem. 1995;270:18841-7 pubmed
Renoir J, Mercier Bodard C, Hoffmann K, Le Bihan S, Ning Y, Sanchez E, et al. Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated g. Proc Natl Acad Sci U S A. 1995;92:4977-81 pubmed
Tanaka H, Makino Y, Dahlman Wright K, Gustafsson J, Okamoto K, Makino I, et al. Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid receptor function at physiological concentrations. Mol Pharmacol. 1995;48:938-45 pubmed
Gametchu B, Harrison R. Characterization of a monoclonal antibody to the rat liver glucocorticoid receptor. Endocrinology. 1984;114:274-9 pubmed
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Hendry W, Danzo B, Harrison R. Analysis of the disruptive action of an epididymal protease and the stabilizing influence of molybdate on nondenatured and denatured glucocorticoid receptor. Endocrinology. 1987;120:629-39 pubmed
Bresnick E, Sanchez E, Pratt W. Relationship between glucocorticoid receptor steroid-binding capacity and association of the Mr 90,000 heat shock protein with the unliganded receptor. J Steroid Biochem. 1988;30:267-9 pubmed
LaFond R, Kennedy S, Harrison R, Villee C. Immunocytochemical localization of glucocorticoid receptors in cells, cytoplasts, and nucleoplasts. Exp Cell Res. 1988;175:52-62 pubmed
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Hutchison K, Brott B, De Leon J, Perdew G, Jove R, Pratt W. Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system. J Biol Chem. 1992;267:2902-8 pubmed
图像
图像 1 :
赛默飞世尔 MA1-510 图像 1
Immunofluorescent analysis of Glucocorticoid Receptor using Glucocorticoid Receptor Monoclonal Antibody (BuGR2) (Product# MA1-510 ) shows staining in A549 Cells. Glucocorticoid Receptor (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with an antibody recognizing Glucocorticoid Receptor (Product# MA1-510 ) at a dilution of 1:100 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
图像 2 :
赛默飞世尔 MA1-510 图像 2
Immunofluorescent analysis of Glucocorticoid Receptor using Glucocorticoid Receptor Monoclonal Antibody (BuGR2) (Product# MA1-510 ) shows staining in Hela Cells. Glucocorticoid Receptor (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with an antibody recognizing Glucocorticoid Receptor (Product# MA1-510 ) at a dilution of 1:100 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
图像 3 :
赛默飞世尔 MA1-510 图像 3
产品信息
产品类型 :
抗体
产品名称 :
糖皮质激素受体单克隆抗体(BuGR2)
目录# :
MA1-510
规格 :
100微克
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Guinea Pig, Human, Mouse, Ovine, Rabbit, Rat, Yeast
应用 :
Flow Cytometry: 1-2 µg/test, Gel Shift: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 5 µg/mL, Immunohistochemistry (PFA fixed): 1:500, Immunoprecipitation: Assay-dependent, Western Blot: 5 µg/mL
物种 :
Guinea Pig, Human, Mouse, Ovine, Rabbit, Rat, Yeast
克隆 :
BuGR2
抗体亚型 :
IgG2a
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity
免疫原 :
Partially purified rat GR.
格式 :
冻干
应用w/稀释 :
Flow Cytometry: 1-2 µg/test, Gel Shift: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 5 µg/mL, Immunohistochemistry (PFA fixed): 1:500, Immunoprecipitation: Assay-dependent, Western Blot: 5 µg/mL
别名 :
cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国