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抗体

LAIR1单克隆抗体(NKTA255)

MA1-33625

500微克

美国550.00

单克隆

小鼠

未共轭

NKTA255

免疫印迹, 免疫沉淀, 流式细胞仪

LAIR1单克隆抗体(NKTA255)

MA1-33625

500微克

美国550.00

单克隆

蛋白质G

小鼠

人类

Flow Cytometry: 1:50-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

人类

NKTA255

IgG1

4° C

LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

NK细胞株B12.100和艾姆斯氏试验.25

液体

Flow Cytometry: 1:50-1:100, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; Lair-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1