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抗体

ZO-1 Recombinant Mouse Monoclonal Antibody (ZO1-1A12), Alexa Fluor™ Plus 488

740002MP488

50微升

美国289.00

重组

小鼠

未共轭

ZO1-1A12

免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片

ZO-1 Recombinant Mouse Monoclonal Antibody (ZO1-1A12), Alexa Fluor™ Plus 488

740002MP488

50微升

美国289.00

重组单克隆

蛋白质A/G

小鼠

人类

Flow Cytometry: 0.063-0.5 µg/test, Immunocytochemistry: 1:2,000-1:4,000, Immunohistochemistry (Paraffin): 1:100

人类

ZO1-1A12

IgG1

4° C, store in dark, DO NOT FREEZE!

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

Human recombinant ZO-1 fusion protein encompassing amino acids 334-634

液体

Flow Cytometry: 0.063-0.5 µg/test, Immunocytochemistry: 1:2,000-1:4,000, Immunohistochemistry (Paraffin): 1:100

DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1