产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
水闸蛋白18重组兔单克隆抗体(34H14L15)
目录 :
700178
规格 :
100微克
价格 :
美国394
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
34H14L15
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 18
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 5c
Flowers B, Xu H, Mulligan A, Hanson K, Seoane J, Vogel H, et al. Cell of Origin Influences Pancreatic Cancer Subtype. Cancer Discov. 2021;11:660-677 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 4b
Lee Thacker S, Jeon H, Choi Y, Taniuchi I, Takarada T, Yoneda Y, et al. Core Binding Factors are essential for ovulation, luteinization, and female fertility in mice. Sci Rep. 2020;10:9921 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:250; 图 7c
Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, et al. Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:2000; 图 2
Krah N, De La O J, Swift G, Hoang C, Willet S, Chen Pan F, et al. The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. elife. 2015;4: pubmed 出版商
  • 免疫印迹; 大鼠
Overgaard C, Schlingmann B, Dorsainvil White S, Ward C, Fan X, Swarnakar S, et al. The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function. Am J Physiol Lung Cell Mol Physiol. 2015;308:L1212-23 pubmed 出版商
  • 免疫组化; 大鼠
Ward C, Schlingmann B, Stecenko A, Guidot D, Koval M. NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation. Tissue Barriers. 2015;3:e982424 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:300
Capella C, Marando A, Longhi E, Bernasconi B, Finzi G, Parravicini C, et al. Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma. Hum Pathol. 2014;45:1310-4 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Jang B, Lee B, Kim W. Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis. PLoS ONE. 2013;8:e82390 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Dainese E, Cimetti L, Capella C, Riva C. Linear and micronodular neuroendocrine cell hyperplasia in an ovarian mucinous cystadenoma. Pathol Res Pract. 2013;209:670-3 pubmed 出版商
Kim S, Shin K, Park J, Lee H, Song K, Lee S, et al. Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer. J Gastric Cancer. 2020;20:408-420 pubmed 出版商
Weber B, Mendler M, Lackner I, von Zelewski A, Höfler S, Baur M, et al. Lung injury after asphyxia and hemorrhagic shock in newborn piglets: Analysis of structural and inflammatory changes. PLoS ONE. 2019;14:e0219211 pubmed 出版商
Coati I, Lotz G, Fanelli G, Brignola S, Lanza C, Cappellesso R, et al. Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. Br J Cancer. 2019;: pubmed 出版商
Chen H, Lu R, Zhang Y, Sun J. Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs. Tissue Barriers. 2018;6:1-13 pubmed 出版商
Luo J, Chimge N, Zhou B, Flodby P, Castaldi A, Firth A, et al. CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018;143:3169-3180 pubmed 出版商
Zhou B, Flodby P, Luo J, Castillo D, Liu Y, Yu F, et al. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018;128:970-984 pubmed 出版商
Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins M, et al. CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice. Cancer Immunol Res. 2014;2:423-35 pubmed 出版商
Zhang Y, Yan W, Collins M, Bednar F, Rakshit S, Zetter B, et al. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res. 2013;73:6359-74 pubmed 出版商
Collins M, Bednar F, Zhang Y, Brisset J, Galban S, Galban C, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest. 2012;122:639-53 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
水闸蛋白18重组兔单克隆抗体(34H14L15)
目录# :
700178
规格 :
100微克
价格 :
美国394
克隆性 :
重组单克隆
纯度 :
蛋白质A
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunohistochemistry: 2-4 µg/mL, Western Blot: 2-3 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
34H14L15
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.
免疫原 :
A peptide corresponding to amino acids 224-237 of P56856.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunohistochemistry: 2-4 µg/mL, Western Blot: 2-3 µg/mL
别名 :
claudin 18; claudin 18-like; claudin-18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; UNQ778/PRO1572
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国